An influenza A virus (H7N9) anti-neuraminidase monoclonal antibody with prophylactic and therapeutic activity in vivo

Zoonotic A(H7N9) avian influenza viruses emerged in China in 2013 and continue to be a threat to human public health, having infected over 800 individuals with a mortality rate approaching 40%. Treatment options for people infected with A(H7N9) include the use of neuraminidase (NA) inhibitors. Howev...

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Veröffentlicht in:	Antiviral research 2016-11, Vol.135, p.48-55
Hauptverfasser:	Wilson, Jason R., Guo, Zhu, Reber, Adrian, Kamal, Ram P., Music, Nedzad, Gansebom, Shane, Bai, Yaohui, Levine, Min, Carney, Paul, Tzeng, Wen-Pin, Stevens, James, York, Ian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibodies, Viral - administration & dosage Antibodies, Viral - immunology Antibodies, Viral - therapeutic use Antiviral Catalytic Domain China Drug Resistance, Viral Epitope Mapping Epitopes - immunology H7N9 Humans Influenza Influenza A Virus, H7N9 Subtype - enzymology Influenza A Virus, H7N9 Subtype - immunology Influenza, Human - prevention & control Influenza, Human - therapy Mice Monoclonal antibody NA epitope Neuraminidase Neuraminidase - antagonists & inhibitors Neuraminidase - chemistry Neuraminidase - immunology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - therapy Orthomyxoviridae Infections - virology Viral Proteins - antagonists & inhibitors Viral Proteins - chemistry Viral Proteins - immunology Virus Replication
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