Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers
Bacteria may play a role in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), although evidence is limited to cross-sectional studies. In this study, we examined the relationship of oral microbiota with EAC and ESCC risk in a prospective study nested in two cohorts. Oral...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2017-12, Vol.77 (23), p.6777-6787 |
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| creator | Peters, Brandilyn A Wu, Jing Pei, Zhiheng Yang, Liying Purdue, Mark P Freedman, Neal D Jacobs, Eric J Gapstur, Susan M Hayes, Richard B Ahn, Jiyoung |
| description | Bacteria may play a role in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), although evidence is limited to cross-sectional studies. In this study, we examined the relationship of oral microbiota with EAC and ESCC risk in a prospective study nested in two cohorts. Oral bacteria were assessed using 16S rRNA gene sequencing in prediagnostic mouthwash samples from
= 81/160 EAC and
= 25/50 ESCC cases/matched controls. Findings were largely consistent across both cohorts. Metagenome content was predicted using PiCRUST. We examined associations between centered log-ratio transformed taxon or functional pathway abundances and risk using conditional logistic regression adjusting for BMI, smoking, and alcohol. We found the periodontal pathogen
to be associated with higher risk of EAC. Furthermore, we found that depletion of the commensal genus
and the species
was associated with lower EAC risk. Bacterial biosynthesis of carotenoids was also associated with protection against EAC. Finally, the abundance of the periodontal pathogen
trended with higher risk of ESCC. Overall, our findings have potential implications for the early detection and prevention of EAC and ESCC.
. |
| doi_str_mv | 10.1158/0008-5472.CAN-17-1296 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5726431</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1971688775</sourcerecordid><originalsourceid>FETCH-LOGICAL-c609t-afbcbbc24d11abf727eea0875a444cd5ed7857e0b205c7f5c03c724862dc0b833</originalsourceid><addsrcrecordid>eNpdkc1u1TAQhS0EopfCI4AisWGT4nHsjLNBqqLyI10oqmBtOc6kdUniYOdW4u1x1HIFrGxrzjma44-xl8DPAJR-yznXpZIoztrzLyVgCaKpH7EdqEqXKKV6zHZHzQl7ltJtfirg6ik7EQ00tQS1Y_vLaMfis3cxdD5MVLRhWkLyqw9zcUXDSG5NxdcY0pJv_o6KK59-FEOIxUUKy429puxv7ewopufsyWDHRC8ezlP2_f3Ft_Zjub_88Kk935eu5s1a2qFzXeeE7AFsN6BAIss1KiuldL2iHrVC4p3gyuGgHK8cCqlr0Tve6ao6Ze_uc5dDN1HvaF5zC7NEP9n4ywTrzb-T2d-Y63BnFIpaVpAD3jwExPDzQGk1k0-OxtHOFA7JQINQa42osvT1f9LbcIhzrpdVuhISEbaN1L0q_2NKkYbjMsDNxstsLMzGwmReBtBsvLLv1d9Njq4_gKrf7W2SUA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1983247713</pqid></control><display><type>article</type><title>Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Peters, Brandilyn A ; Wu, Jing ; Pei, Zhiheng ; Yang, Liying ; Purdue, Mark P ; Freedman, Neal D ; Jacobs, Eric J ; Gapstur, Susan M ; Hayes, Richard B ; Ahn, Jiyoung</creator><creatorcontrib>Peters, Brandilyn A ; Wu, Jing ; Pei, Zhiheng ; Yang, Liying ; Purdue, Mark P ; Freedman, Neal D ; Jacobs, Eric J ; Gapstur, Susan M ; Hayes, Richard B ; Ahn, Jiyoung</creatorcontrib><description>Bacteria may play a role in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), although evidence is limited to cross-sectional studies. In this study, we examined the relationship of oral microbiota with EAC and ESCC risk in a prospective study nested in two cohorts. Oral bacteria were assessed using 16S rRNA gene sequencing in prediagnostic mouthwash samples from
= 81/160 EAC and
= 25/50 ESCC cases/matched controls. Findings were largely consistent across both cohorts. Metagenome content was predicted using PiCRUST. We examined associations between centered log-ratio transformed taxon or functional pathway abundances and risk using conditional logistic regression adjusting for BMI, smoking, and alcohol. We found the periodontal pathogen
to be associated with higher risk of EAC. Furthermore, we found that depletion of the commensal genus
and the species
was associated with lower EAC risk. Bacterial biosynthesis of carotenoids was also associated with protection against EAC. Finally, the abundance of the periodontal pathogen
trended with higher risk of ESCC. Overall, our findings have potential implications for the early detection and prevention of EAC and ESCC.
.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>DOI: 10.1158/0008-5472.CAN-17-1296</identifier><identifier>PMID: 29196415</identifier><language>eng</language><publisher>United States: American Association for Cancer Research, Inc</publisher><subject>Adenocarcinoma ; Adenocarcinoma - epidemiology ; Adenocarcinoma - microbiology ; Aged ; Alcoholic beverages ; Alcohols ; Bacteria ; Biosynthesis ; Body mass ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - microbiology ; Carotenoids ; Case-Control Studies ; Esophageal cancer ; Esophageal Neoplasms - epidemiology ; Esophageal Neoplasms - microbiology ; Esophageal Squamous Cell Carcinoma ; Esophagus ; Female ; Health risk assessment ; Health risks ; Humans ; Male ; Microbiomes ; Microbiota ; Microbiota - genetics ; Microorganisms ; Middle Aged ; Mouth - microbiology ; Neisseria - classification ; Neisseria - genetics ; Neisseria - isolation & purification ; Pathogens ; Periodontics ; Porphyromonas gingivalis - classification ; Porphyromonas gingivalis - genetics ; Porphyromonas gingivalis - isolation & purification ; Prospective Studies ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Smoking ; Squamous cell carcinoma ; Streptococcus infections ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - genetics ; Streptococcus pneumoniae - isolation & purification ; Surveys and Questionnaires ; Tannerella forsythia - classification ; Tannerella forsythia - genetics ; Tannerella forsythia - isolation & purification</subject><ispartof>Cancer research (Chicago, Ill.), 2017-12, Vol.77 (23), p.6777-6787</ispartof><rights>2017 American Association for Cancer Research.</rights><rights>Copyright American Association for Cancer Research, Inc. Dec 1, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-afbcbbc24d11abf727eea0875a444cd5ed7857e0b205c7f5c03c724862dc0b833</citedby><cites>FETCH-LOGICAL-c609t-afbcbbc24d11abf727eea0875a444cd5ed7857e0b205c7f5c03c724862dc0b833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29196415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peters, Brandilyn A</creatorcontrib><creatorcontrib>Wu, Jing</creatorcontrib><creatorcontrib>Pei, Zhiheng</creatorcontrib><creatorcontrib>Yang, Liying</creatorcontrib><creatorcontrib>Purdue, Mark P</creatorcontrib><creatorcontrib>Freedman, Neal D</creatorcontrib><creatorcontrib>Jacobs, Eric J</creatorcontrib><creatorcontrib>Gapstur, Susan M</creatorcontrib><creatorcontrib>Hayes, Richard B</creatorcontrib><creatorcontrib>Ahn, Jiyoung</creatorcontrib><title>Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Bacteria may play a role in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), although evidence is limited to cross-sectional studies. In this study, we examined the relationship of oral microbiota with EAC and ESCC risk in a prospective study nested in two cohorts. Oral bacteria were assessed using 16S rRNA gene sequencing in prediagnostic mouthwash samples from
= 81/160 EAC and
= 25/50 ESCC cases/matched controls. Findings were largely consistent across both cohorts. Metagenome content was predicted using PiCRUST. We examined associations between centered log-ratio transformed taxon or functional pathway abundances and risk using conditional logistic regression adjusting for BMI, smoking, and alcohol. We found the periodontal pathogen
to be associated with higher risk of EAC. Furthermore, we found that depletion of the commensal genus
and the species
was associated with lower EAC risk. Bacterial biosynthesis of carotenoids was also associated with protection against EAC. Finally, the abundance of the periodontal pathogen
trended with higher risk of ESCC. Overall, our findings have potential implications for the early detection and prevention of EAC and ESCC.
.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - epidemiology</subject><subject>Adenocarcinoma - microbiology</subject><subject>Aged</subject><subject>Alcoholic beverages</subject><subject>Alcohols</subject><subject>Bacteria</subject><subject>Biosynthesis</subject><subject>Body mass</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - microbiology</subject><subject>Carotenoids</subject><subject>Case-Control Studies</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Esophageal Neoplasms - microbiology</subject><subject>Esophageal Squamous Cell Carcinoma</subject><subject>Esophagus</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Male</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microbiota - genetics</subject><subject>Microorganisms</subject><subject>Middle Aged</subject><subject>Mouth - microbiology</subject><subject>Neisseria - classification</subject><subject>Neisseria - genetics</subject><subject>Neisseria - isolation & purification</subject><subject>Pathogens</subject><subject>Periodontics</subject><subject>Porphyromonas gingivalis - classification</subject><subject>Porphyromonas gingivalis - genetics</subject><subject>Porphyromonas gingivalis - isolation & purification</subject><subject>Prospective Studies</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>rRNA 16S</subject><subject>Smoking</subject><subject>Squamous cell carcinoma</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Streptococcus pneumoniae - genetics</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Surveys and Questionnaires</subject><subject>Tannerella forsythia - classification</subject><subject>Tannerella forsythia - genetics</subject><subject>Tannerella forsythia - isolation & purification</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1u1TAQhS0EopfCI4AisWGT4nHsjLNBqqLyI10oqmBtOc6kdUniYOdW4u1x1HIFrGxrzjma44-xl8DPAJR-yznXpZIoztrzLyVgCaKpH7EdqEqXKKV6zHZHzQl7ltJtfirg6ik7EQ00tQS1Y_vLaMfis3cxdD5MVLRhWkLyqw9zcUXDSG5NxdcY0pJv_o6KK59-FEOIxUUKy429puxv7ewopufsyWDHRC8ezlP2_f3Ft_Zjub_88Kk935eu5s1a2qFzXeeE7AFsN6BAIss1KiuldL2iHrVC4p3gyuGgHK8cCqlr0Tve6ao6Ze_uc5dDN1HvaF5zC7NEP9n4ywTrzb-T2d-Y63BnFIpaVpAD3jwExPDzQGk1k0-OxtHOFA7JQINQa42osvT1f9LbcIhzrpdVuhISEbaN1L0q_2NKkYbjMsDNxstsLMzGwmReBtBsvLLv1d9Njq4_gKrf7W2SUA</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Peters, Brandilyn A</creator><creator>Wu, Jing</creator><creator>Pei, Zhiheng</creator><creator>Yang, Liying</creator><creator>Purdue, Mark P</creator><creator>Freedman, Neal D</creator><creator>Jacobs, Eric J</creator><creator>Gapstur, Susan M</creator><creator>Hayes, Richard B</creator><creator>Ahn, Jiyoung</creator><general>American Association for Cancer Research, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171201</creationdate><title>Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers</title><author>Peters, Brandilyn A ; Wu, Jing ; Pei, Zhiheng ; Yang, Liying ; Purdue, Mark P ; Freedman, Neal D ; Jacobs, Eric J ; Gapstur, Susan M ; Hayes, Richard B ; Ahn, Jiyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-afbcbbc24d11abf727eea0875a444cd5ed7857e0b205c7f5c03c724862dc0b833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - epidemiology</topic><topic>Adenocarcinoma - microbiology</topic><topic>Aged</topic><topic>Alcoholic beverages</topic><topic>Alcohols</topic><topic>Bacteria</topic><topic>Biosynthesis</topic><topic>Body mass</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - microbiology</topic><topic>Carotenoids</topic><topic>Case-Control Studies</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - epidemiology</topic><topic>Esophageal Neoplasms - microbiology</topic><topic>Esophageal Squamous Cell Carcinoma</topic><topic>Esophagus</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Humans</topic><topic>Male</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microbiota - genetics</topic><topic>Microorganisms</topic><topic>Middle Aged</topic><topic>Mouth - microbiology</topic><topic>Neisseria - classification</topic><topic>Neisseria - genetics</topic><topic>Neisseria - isolation & purification</topic><topic>Pathogens</topic><topic>Periodontics</topic><topic>Porphyromonas gingivalis - classification</topic><topic>Porphyromonas gingivalis - genetics</topic><topic>Porphyromonas gingivalis - isolation & purification</topic><topic>Prospective Studies</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>rRNA 16S</topic><topic>Smoking</topic><topic>Squamous cell carcinoma</topic><topic>Streptococcus infections</topic><topic>Streptococcus pneumoniae - classification</topic><topic>Streptococcus pneumoniae - genetics</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><topic>Surveys and Questionnaires</topic><topic>Tannerella forsythia - classification</topic><topic>Tannerella forsythia - genetics</topic><topic>Tannerella forsythia - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peters, Brandilyn A</creatorcontrib><creatorcontrib>Wu, Jing</creatorcontrib><creatorcontrib>Pei, Zhiheng</creatorcontrib><creatorcontrib>Yang, Liying</creatorcontrib><creatorcontrib>Purdue, Mark P</creatorcontrib><creatorcontrib>Freedman, Neal D</creatorcontrib><creatorcontrib>Jacobs, Eric J</creatorcontrib><creatorcontrib>Gapstur, Susan M</creatorcontrib><creatorcontrib>Hayes, Richard B</creatorcontrib><creatorcontrib>Ahn, Jiyoung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peters, Brandilyn A</au><au>Wu, Jing</au><au>Pei, Zhiheng</au><au>Yang, Liying</au><au>Purdue, Mark P</au><au>Freedman, Neal D</au><au>Jacobs, Eric J</au><au>Gapstur, Susan M</au><au>Hayes, Richard B</au><au>Ahn, Jiyoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>77</volume><issue>23</issue><spage>6777</spage><epage>6787</epage><pages>6777-6787</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><abstract>Bacteria may play a role in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), although evidence is limited to cross-sectional studies. In this study, we examined the relationship of oral microbiota with EAC and ESCC risk in a prospective study nested in two cohorts. Oral bacteria were assessed using 16S rRNA gene sequencing in prediagnostic mouthwash samples from
= 81/160 EAC and
= 25/50 ESCC cases/matched controls. Findings were largely consistent across both cohorts. Metagenome content was predicted using PiCRUST. We examined associations between centered log-ratio transformed taxon or functional pathway abundances and risk using conditional logistic regression adjusting for BMI, smoking, and alcohol. We found the periodontal pathogen
to be associated with higher risk of EAC. Furthermore, we found that depletion of the commensal genus
and the species
was associated with lower EAC risk. Bacterial biosynthesis of carotenoids was also associated with protection against EAC. Finally, the abundance of the periodontal pathogen
trended with higher risk of ESCC. Overall, our findings have potential implications for the early detection and prevention of EAC and ESCC.
.</abstract><cop>United States</cop><pub>American Association for Cancer Research, Inc</pub><pmid>29196415</pmid><doi>10.1158/0008-5472.CAN-17-1296</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma - epidemiology Adenocarcinoma - microbiology Aged Alcoholic beverages Alcohols Bacteria Biosynthesis Body mass Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - microbiology Carotenoids Case-Control Studies Esophageal cancer Esophageal Neoplasms - epidemiology Esophageal Neoplasms - microbiology Esophageal Squamous Cell Carcinoma Esophagus Female Health risk assessment Health risks Humans Male Microbiomes Microbiota Microbiota - genetics Microorganisms Middle Aged Mouth - microbiology Neisseria - classification Neisseria - genetics Neisseria - isolation & purification Pathogens Periodontics Porphyromonas gingivalis - classification Porphyromonas gingivalis - genetics Porphyromonas gingivalis - isolation & purification Prospective Studies RNA, Ribosomal, 16S - genetics rRNA 16S Smoking Squamous cell carcinoma Streptococcus infections Streptococcus pneumoniae - classification Streptococcus pneumoniae - genetics Streptococcus pneumoniae - isolation & purification Surveys and Questionnaires Tannerella forsythia - classification Tannerella forsythia - genetics Tannerella forsythia - isolation & purification |
| title | Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers |
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