Synthesis and Structure–Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors

The melanocortin system is involved in the regulation of several complex physiological functions. In particular, the melanocortin-3 and -4 receptors (MC3R/MC4R) have been demonstrated to regulate body weight, energy homeostasis, and feeding behavior. Synthetic and endogenous melanocortin agonists ha...

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Veröffentlicht in:	ACS chemical neuroscience 2016-02, Vol.7 (2), p.196-205
Hauptverfasser:	Singh, Anamika, Kast, Johannes, Dirain, Marvin L. S, Huang, Huisuo, Haskell-Luevano, Carrie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Galactosidase - genetics beta-Galactosidase - metabolism Drug Compounding HEK293 Cells Humans Ligands Mice Mutation - genetics Receptor, Melanocortin, Type 3 - agonists Receptor, Melanocortin, Type 3 - genetics Receptor, Melanocortin, Type 3 - metabolism Receptor, Melanocortin, Type 4 - agonists Receptor, Melanocortin, Type 4 - genetics Receptor, Melanocortin, Type 4 - metabolism Solid-Phase Synthesis Techniques Structure-Activity Relationship Transfection Urea - metabolism
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