The unique calcium chelation property of poly(vinyl phosphonic acid‐co‐acrylic acid) and effects on osteogenesis in vitro

There is a clear clinical need for a bioactive bone graft substitute. Poly(vinyl phosphonic acid‐co‐acrylic acid) (PVPA‐co‐AA) has been identified as a promising candidate for bone regeneration but there is little evidence to show its direct osteogenic effect on progenitor or mature cells. In this s...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2018-01, Vol.106 (1), p.168-179
Hauptverfasser:	Wang, Qi Guang, Wimpenny, Ian, Dey, Rebecca E., Zhong, Xia, Youle, Peter J., Downes, Sandra, Watts, David C., Budd, Peter M., Hoyland, Judith A., Gough, Julie E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Acrylates - chemistry Acrylates - pharmacology Acrylic acid Antibiotics Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biological activity Biomedical materials Bone growth Bone marrow Bone Regeneration - drug effects Bone Transplantation - methods Bones Calcium Calcium Chelating Agents - chemistry Calcium Chelating Agents - pharmacology calcium chelation Cell Differentiation - drug effects Cell Line, Tumor Chelation Design engineering Grafting Humans Mesenchymal Stem Cells - drug effects Mesenchyme Mineralization Organophosphonates - chemistry Organophosphonates - pharmacology Original Osteoblasts - drug effects Osteoconduction osteoconductivity Osteogenesis Osteogenesis - drug effects osteoinductivity Polymers Polymers - chemistry Polymers - pharmacology polyvinyl phosphonic acid Polyvinyls - chemistry Polyvinyls - pharmacology Regeneration Regeneration (physiology) Scaffolds Stem cells Therapeutic applications Tissue Adhesives - chemistry Tissue Adhesives - pharmacology Tissue Engineering Valproic acid
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