The unique calcium chelation property of poly(vinyl phosphonic acid‐co‐acrylic acid) and effects on osteogenesis in vitro
There is a clear clinical need for a bioactive bone graft substitute. Poly(vinyl phosphonic acid‐co‐acrylic acid) (PVPA‐co‐AA) has been identified as a promising candidate for bone regeneration but there is little evidence to show its direct osteogenic effect on progenitor or mature cells. In this s...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2018-01, Vol.106 (1), p.168-179 |
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| container_title | Journal of biomedical materials research. Part A |
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| creator | Wang, Qi Guang Wimpenny, Ian Dey, Rebecca E. Zhong, Xia Youle, Peter J. Downes, Sandra Watts, David C. Budd, Peter M. Hoyland, Judith A. Gough, Julie E. |
| description | There is a clear clinical need for a bioactive bone graft substitute. Poly(vinyl phosphonic acid‐co‐acrylic acid) (PVPA‐co‐AA) has been identified as a promising candidate for bone regeneration but there is little evidence to show its direct osteogenic effect on progenitor or mature cells. In this study mature osteoblast‐like cells (SaOS‐2) and human bone marrow‐derived mesenchymal stem cells (hBM‐MSCs) were cultured with PVPA‐co‐AA polymers with different VPA:AA ratio and at different concentrations in vitro. We are the first to report the direct osteogenic effect of PVPA‐co‐AA polymer on bone cells and, more importantly, this effect was dependent on VPA:AA ratio and concentration. Under the optimized conditions, PVPA‐co‐AA polymer not only has an osteoconductive effect, enhancing SaOS‐2 cell mineralization, but also has an osteoinductive effect to promote hBM‐MSCs’ osteogenic differentiation. Notably, the same PVPA‐co‐AA polymer at different concentrations could lead to differential osteogenic effects on both SaOS‐2 and hBM‐MSCs in vitro. This study furthers knowledge of the PVPA‐co‐AA polymer in osteogenic studies, which is critical when utilizing the PVPA‐co‐AA polymer for the design of novel bioactive polymeric tissue engineering scaffolds for future clinical applications. © 2017 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 168–179, 2018. |
| doi_str_mv | 10.1002/jbm.a.36223 |
| format | Article |
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Poly(vinyl phosphonic acid‐co‐acrylic acid) (PVPA‐co‐AA) has been identified as a promising candidate for bone regeneration but there is little evidence to show its direct osteogenic effect on progenitor or mature cells. In this study mature osteoblast‐like cells (SaOS‐2) and human bone marrow‐derived mesenchymal stem cells (hBM‐MSCs) were cultured with PVPA‐co‐AA polymers with different VPA:AA ratio and at different concentrations in vitro. We are the first to report the direct osteogenic effect of PVPA‐co‐AA polymer on bone cells and, more importantly, this effect was dependent on VPA:AA ratio and concentration. Under the optimized conditions, PVPA‐co‐AA polymer not only has an osteoconductive effect, enhancing SaOS‐2 cell mineralization, but also has an osteoinductive effect to promote hBM‐MSCs’ osteogenic differentiation. Notably, the same PVPA‐co‐AA polymer at different concentrations could lead to differential osteogenic effects on both SaOS‐2 and hBM‐MSCs in vitro. This study furthers knowledge of the PVPA‐co‐AA polymer in osteogenic studies, which is critical when utilizing the PVPA‐co‐AA polymer for the design of novel bioactive polymeric tissue engineering scaffolds for future clinical applications. © 2017 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 168–179, 2018.</description><identifier>ISSN: 1549-3296</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.36223</identifier><identifier>PMID: 28884508</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Acids ; Acrylates - chemistry ; Acrylates - pharmacology ; Acrylic acid ; Antibiotics ; Biocompatibility ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biological activity ; Biomedical materials ; Bone growth ; Bone marrow ; Bone Regeneration - drug effects ; Bone Transplantation - methods ; Bones ; Calcium ; Calcium Chelating Agents - chemistry ; Calcium Chelating Agents - pharmacology ; calcium chelation ; Cell Differentiation - drug effects ; Cell Line, Tumor ; Chelation ; Design engineering ; Grafting ; Humans ; Mesenchymal Stem Cells - drug effects ; Mesenchyme ; Mineralization ; Organophosphonates - chemistry ; Organophosphonates - pharmacology ; Original ; Osteoblasts - drug effects ; Osteoconduction ; osteoconductivity ; Osteogenesis ; Osteogenesis - drug effects ; osteoinductivity ; Polymers ; Polymers - chemistry ; Polymers - pharmacology ; polyvinyl phosphonic acid ; Polyvinyls - chemistry ; Polyvinyls - pharmacology ; Regeneration ; Regeneration (physiology) ; Scaffolds ; Stem cells ; Therapeutic applications ; Tissue Adhesives - chemistry ; Tissue Adhesives - pharmacology ; Tissue Engineering ; Valproic acid</subject><ispartof>Journal of biomedical materials research. Part A, 2018-01, Vol.106 (1), p.168-179</ispartof><rights>2017 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4893-52194f3d1c3ce93897c90bba11fef4fabe6afe911988940d9b5b6da1d3252c703</citedby><cites>FETCH-LOGICAL-c4893-52194f3d1c3ce93897c90bba11fef4fabe6afe911988940d9b5b6da1d3252c703</cites><orcidid>0000-0003-3040-5810 ; 0000-0003-3606-1158</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.a.36223$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.a.36223$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28884508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Qi Guang</creatorcontrib><creatorcontrib>Wimpenny, Ian</creatorcontrib><creatorcontrib>Dey, Rebecca E.</creatorcontrib><creatorcontrib>Zhong, Xia</creatorcontrib><creatorcontrib>Youle, Peter J.</creatorcontrib><creatorcontrib>Downes, Sandra</creatorcontrib><creatorcontrib>Watts, David C.</creatorcontrib><creatorcontrib>Budd, Peter M.</creatorcontrib><creatorcontrib>Hoyland, Judith A.</creatorcontrib><creatorcontrib>Gough, Julie E.</creatorcontrib><title>The unique calcium chelation property of poly(vinyl phosphonic acid‐co‐acrylic acid) and effects on osteogenesis in vitro</title><title>Journal of biomedical materials research. Part A</title><addtitle>J Biomed Mater Res A</addtitle><description>There is a clear clinical need for a bioactive bone graft substitute. Poly(vinyl phosphonic acid‐co‐acrylic acid) (PVPA‐co‐AA) has been identified as a promising candidate for bone regeneration but there is little evidence to show its direct osteogenic effect on progenitor or mature cells. In this study mature osteoblast‐like cells (SaOS‐2) and human bone marrow‐derived mesenchymal stem cells (hBM‐MSCs) were cultured with PVPA‐co‐AA polymers with different VPA:AA ratio and at different concentrations in vitro. We are the first to report the direct osteogenic effect of PVPA‐co‐AA polymer on bone cells and, more importantly, this effect was dependent on VPA:AA ratio and concentration. Under the optimized conditions, PVPA‐co‐AA polymer not only has an osteoconductive effect, enhancing SaOS‐2 cell mineralization, but also has an osteoinductive effect to promote hBM‐MSCs’ osteogenic differentiation. Notably, the same PVPA‐co‐AA polymer at different concentrations could lead to differential osteogenic effects on both SaOS‐2 and hBM‐MSCs in vitro. This study furthers knowledge of the PVPA‐co‐AA polymer in osteogenic studies, which is critical when utilizing the PVPA‐co‐AA polymer for the design of novel bioactive polymeric tissue engineering scaffolds for future clinical applications. © 2017 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 168–179, 2018.</description><subject>Acids</subject><subject>Acrylates - chemistry</subject><subject>Acrylates - pharmacology</subject><subject>Acrylic acid</subject><subject>Antibiotics</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>Bone growth</subject><subject>Bone marrow</subject><subject>Bone Regeneration - drug effects</subject><subject>Bone Transplantation - methods</subject><subject>Bones</subject><subject>Calcium</subject><subject>Calcium Chelating Agents - chemistry</subject><subject>Calcium Chelating Agents - pharmacology</subject><subject>calcium chelation</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Chelation</subject><subject>Design engineering</subject><subject>Grafting</subject><subject>Humans</subject><subject>Mesenchymal Stem Cells - drug effects</subject><subject>Mesenchyme</subject><subject>Mineralization</subject><subject>Organophosphonates - chemistry</subject><subject>Organophosphonates - pharmacology</subject><subject>Original</subject><subject>Osteoblasts - drug effects</subject><subject>Osteoconduction</subject><subject>osteoconductivity</subject><subject>Osteogenesis</subject><subject>Osteogenesis - drug effects</subject><subject>osteoinductivity</subject><subject>Polymers</subject><subject>Polymers - chemistry</subject><subject>Polymers - pharmacology</subject><subject>polyvinyl phosphonic acid</subject><subject>Polyvinyls - chemistry</subject><subject>Polyvinyls - pharmacology</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Scaffolds</subject><subject>Stem cells</subject><subject>Therapeutic applications</subject><subject>Tissue Adhesives - chemistry</subject><subject>Tissue Adhesives - pharmacology</subject><subject>Tissue Engineering</subject><subject>Valproic acid</subject><issn>1549-3296</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kctu1DAUhiMEohdYsUeW2LRCGWI7ztgbpLaiXFTEpqwtxznueOTYwU4GZVGJR-AZeZJ6OkMFLFj4IvvTd479F8ULXC1wVZE367ZfqAVtCKGPikPMGClr0bDH230tSkpEc1AcpbTOcFMx8rQ4IJzzmlX8sLi9XgGavP02AdLKaTv1SK_AqdEGj4YYBojjjIJBQ3Dzycb62aFhFVIe3mqktO1-_fipQ56UjrPbn50i5TsExoAeE8qqkEYIN-Ah2YSsRxs7xvCseGKUS_B8vx4XXy_fXV98KK--vP94cXZV6poLWjKCRW1ohzXVICgXSy2qtlUYGzC1US00yoDAWHAu6qoTLWubTuGOEkb0sqLHxdudd5jaHjoNfozKySHaXsVZBmXl3zferuRN2Ei2JKzhdRac7AUx5K9Ko-xt0uCc8hCmJLGgS0YYv6_16h90Habo8_My1XCSGyRb6vWO0jGkFME8NIMruY1V5lilkvexZvrln_0_sL9zzADZAd-tg_l_Lvnp_PPZznoHOA2yrw</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Wang, Qi Guang</creator><creator>Wimpenny, Ian</creator><creator>Dey, Rebecca E.</creator><creator>Zhong, Xia</creator><creator>Youle, Peter J.</creator><creator>Downes, Sandra</creator><creator>Watts, David C.</creator><creator>Budd, Peter M.</creator><creator>Hoyland, Judith A.</creator><creator>Gough, Julie E.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3040-5810</orcidid><orcidid>https://orcid.org/0000-0003-3606-1158</orcidid></search><sort><creationdate>201801</creationdate><title>The unique calcium chelation property of poly(vinyl phosphonic acid‐co‐acrylic acid) and effects on osteogenesis in vitro</title><author>Wang, Qi Guang ; Wimpenny, Ian ; Dey, Rebecca E. ; Zhong, Xia ; Youle, Peter J. ; Downes, Sandra ; Watts, David C. ; Budd, Peter M. ; Hoyland, Judith A. ; Gough, Julie E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4893-52194f3d1c3ce93897c90bba11fef4fabe6afe911988940d9b5b6da1d3252c703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acids</topic><topic>Acrylates - chemistry</topic><topic>Acrylates - pharmacology</topic><topic>Acrylic acid</topic><topic>Antibiotics</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biological activity</topic><topic>Biomedical materials</topic><topic>Bone growth</topic><topic>Bone marrow</topic><topic>Bone Regeneration - drug effects</topic><topic>Bone Transplantation - methods</topic><topic>Bones</topic><topic>Calcium</topic><topic>Calcium Chelating Agents - chemistry</topic><topic>Calcium Chelating Agents - pharmacology</topic><topic>calcium chelation</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Chelation</topic><topic>Design engineering</topic><topic>Grafting</topic><topic>Humans</topic><topic>Mesenchymal Stem Cells - drug effects</topic><topic>Mesenchyme</topic><topic>Mineralization</topic><topic>Organophosphonates - chemistry</topic><topic>Organophosphonates - pharmacology</topic><topic>Original</topic><topic>Osteoblasts - drug effects</topic><topic>Osteoconduction</topic><topic>osteoconductivity</topic><topic>Osteogenesis</topic><topic>Osteogenesis - drug effects</topic><topic>osteoinductivity</topic><topic>Polymers</topic><topic>Polymers - chemistry</topic><topic>Polymers - pharmacology</topic><topic>polyvinyl phosphonic acid</topic><topic>Polyvinyls - chemistry</topic><topic>Polyvinyls - pharmacology</topic><topic>Regeneration</topic><topic>Regeneration (physiology)</topic><topic>Scaffolds</topic><topic>Stem cells</topic><topic>Therapeutic applications</topic><topic>Tissue Adhesives - chemistry</topic><topic>Tissue Adhesives - pharmacology</topic><topic>Tissue Engineering</topic><topic>Valproic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Qi Guang</creatorcontrib><creatorcontrib>Wimpenny, Ian</creatorcontrib><creatorcontrib>Dey, Rebecca E.</creatorcontrib><creatorcontrib>Zhong, Xia</creatorcontrib><creatorcontrib>Youle, Peter J.</creatorcontrib><creatorcontrib>Downes, Sandra</creatorcontrib><creatorcontrib>Watts, David C.</creatorcontrib><creatorcontrib>Budd, Peter M.</creatorcontrib><creatorcontrib>Hoyland, Judith A.</creatorcontrib><creatorcontrib>Gough, Julie E.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomedical materials research. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Qi Guang</au><au>Wimpenny, Ian</au><au>Dey, Rebecca E.</au><au>Zhong, Xia</au><au>Youle, Peter J.</au><au>Downes, Sandra</au><au>Watts, David C.</au><au>Budd, Peter M.</au><au>Hoyland, Judith A.</au><au>Gough, Julie E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The unique calcium chelation property of poly(vinyl phosphonic acid‐co‐acrylic acid) and effects on osteogenesis in vitro</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J Biomed Mater Res A</addtitle><date>2018-01</date><risdate>2018</risdate><volume>106</volume><issue>1</issue><spage>168</spage><epage>179</epage><pages>168-179</pages><issn>1549-3296</issn><eissn>1552-4965</eissn><abstract>There is a clear clinical need for a bioactive bone graft substitute. Poly(vinyl phosphonic acid‐co‐acrylic acid) (PVPA‐co‐AA) has been identified as a promising candidate for bone regeneration but there is little evidence to show its direct osteogenic effect on progenitor or mature cells. In this study mature osteoblast‐like cells (SaOS‐2) and human bone marrow‐derived mesenchymal stem cells (hBM‐MSCs) were cultured with PVPA‐co‐AA polymers with different VPA:AA ratio and at different concentrations in vitro. We are the first to report the direct osteogenic effect of PVPA‐co‐AA polymer on bone cells and, more importantly, this effect was dependent on VPA:AA ratio and concentration. Under the optimized conditions, PVPA‐co‐AA polymer not only has an osteoconductive effect, enhancing SaOS‐2 cell mineralization, but also has an osteoinductive effect to promote hBM‐MSCs’ osteogenic differentiation. Notably, the same PVPA‐co‐AA polymer at different concentrations could lead to differential osteogenic effects on both SaOS‐2 and hBM‐MSCs in vitro. This study furthers knowledge of the PVPA‐co‐AA polymer in osteogenic studies, which is critical when utilizing the PVPA‐co‐AA polymer for the design of novel bioactive polymeric tissue engineering scaffolds for future clinical applications. © 2017 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 168–179, 2018.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28884508</pmid><doi>10.1002/jbm.a.36223</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-3040-5810</orcidid><orcidid>https://orcid.org/0000-0003-3606-1158</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acids Acrylates - chemistry Acrylates - pharmacology Acrylic acid Antibiotics Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biological activity Biomedical materials Bone growth Bone marrow Bone Regeneration - drug effects Bone Transplantation - methods Bones Calcium Calcium Chelating Agents - chemistry Calcium Chelating Agents - pharmacology calcium chelation Cell Differentiation - drug effects Cell Line, Tumor Chelation Design engineering Grafting Humans Mesenchymal Stem Cells - drug effects Mesenchyme Mineralization Organophosphonates - chemistry Organophosphonates - pharmacology Original Osteoblasts - drug effects Osteoconduction osteoconductivity Osteogenesis Osteogenesis - drug effects osteoinductivity Polymers Polymers - chemistry Polymers - pharmacology polyvinyl phosphonic acid Polyvinyls - chemistry Polyvinyls - pharmacology Regeneration Regeneration (physiology) Scaffolds Stem cells Therapeutic applications Tissue Adhesives - chemistry Tissue Adhesives - pharmacology Tissue Engineering Valproic acid |
| title | The unique calcium chelation property of poly(vinyl phosphonic acid‐co‐acrylic acid) and effects on osteogenesis in vitro |
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