Role of Dopamine Receptors in the Anticancer Activity of ONC20112

ONC201/TIC10 is a first-in-class small molecule inducer of TRAIL that causes early activation of the integrated stress response. Its promising safety profile and broad-spectrum efficacy in vitro have been confirmed in Phase I/II trials in several advanced malignancies. Binding and reporter assays ha...

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Veröffentlicht in:	Neoplasia (New York, N.Y.) N.Y.), 2017-12, Vol.20 (1), p.80-91
Hauptverfasser:	Kline, Christina Leah B., Ralff, Marie D., Lulla, Amriti R., Wagner, Jessica M., Abbosh, Phillip H., Dicker, David T., Allen, Joshua E., El-Deiry, Wafik S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Original article
Online-Zugang:	Volltext
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