G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia

We show that the G protein‐coupled receptor GPR37‐like 1 (GPR37L1) is expressed in most astrocytes and some oligodendrocyte precursors in the mouse central nervous system. This contrasts with GPR37, which is mainly in mature oligodendrocytes. Comparison of wild type and Gpr37l1–/– mice showed that l...

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Veröffentlicht in:	Glia 2018-01, Vol.66 (1), p.47-61
Hauptverfasser:	Jolly, Sarah, Bazargani, Narges, Quiroga, Alejandra C., Pringle, Nigel P., Attwell, David, Richardson, William D., Li, Huiliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - genetics Activation Amino Acid Transport System X-AG - metabolism Animals Animals, Newborn Aspartic Acid - pharmacology Astrocytes Astrocytes - drug effects Astrocytes - metabolism Brain Brain - pathology Central nervous system Cerebral blood flow D-Serine Disease Models, Animal Exploratory Behavior - physiology Gene Expression Regulation, Developmental - genetics Glial stem cells Glutamic acid receptors (ionotropic) Gpr37l1 knockout mice Gpr37l1‐GFP mice Hippocampus - cytology Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Infarction, Middle Cerebral Artery - therapy Ischemia MCAO Membrane potential Mice Mice, Inbred C57BL Mice, Transgenic Mutation - genetics N-Methyl-D-aspartic acid receptors N-Methylaspartate - pharmacology Neural stem cells Neurons Neurons - metabolism Neurons - physiology Neuroprotection Occlusion Oligodendrocytes prosaposin Receptors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Recognition, Psychology - physiology Rodents Signaling
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