Proteomics Identifies Golgi phosphoprotein 3 (GOLPH3) with A Link Between Golgi Structure, Cancer, DNA Damage and Protection from Cell Death
GOLPH3 is the first example of a Golgi resident oncogene protein. It was independently identified in multiple screens; first in proteomic-based screens as a resident protein of the Golgi apparatus, and second as an oncogene product in a screen for genes amplified in cancer. A third screen uncovered...
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| Veröffentlicht in: | Molecular & cellular proteomics 2017-12, Vol.16 (12), p.2048-2054 |
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| container_title | Molecular & cellular proteomics |
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| creator | Bergeron, John J.M. Au, Catherine E. Thomas, David Y. Hermo, Louis |
| description | GOLPH3 is the first example of a Golgi resident oncogene protein. It was independently identified in multiple screens; first in proteomic-based screens as a resident protein of the Golgi apparatus, and second as an oncogene product in a screen for genes amplified in cancer. A third screen uncovered the association of GOLPH3 with the Golgi resident phospholipid, phosphatidyl inositol 4 phosphate (PI4P) to maintain the characteristic ribbon structure of the Golgi apparatus favoring vesicular transport of secretory proteins. |
| doi_str_mv | 10.1074/mcp.MR117.000068 |
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It was independently identified in multiple screens; first in proteomic-based screens as a resident protein of the Golgi apparatus, and second as an oncogene product in a screen for genes amplified in cancer. A third screen uncovered the association of GOLPH3 with the Golgi resident phospholipid, phosphatidyl inositol 4 phosphate (PI4P) to maintain the characteristic ribbon structure of the Golgi apparatus favoring vesicular transport of secretory proteins.</description><identifier>ISSN: 1535-9476</identifier><identifier>EISSN: 1535-9484</identifier><identifier>DOI: 10.1074/mcp.MR117.000068</identifier><identifier>PMID: 28954815</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cancer ; Cell Death ; Deoxyribonucleic acid ; DNA ; DNA Damage ; DNA structure ; Gene Amplification ; Golgi apparatus ; Golgi Apparatus - chemistry ; Golgi Apparatus - metabolism ; Humans ; Liver - metabolism ; Membrane Proteins - chemistry ; Membrane Proteins - metabolism ; Mini Review ; Models, Molecular ; Neoplasms - metabolism ; Phosphates ; Phosphatidylinositol Phosphates - metabolism ; Phospholipids ; Protein Structure, Tertiary ; Proteins ; Proteomics ; Proteomics - methods ; Screens ; Structural damage</subject><ispartof>Molecular & cellular proteomics, 2017-12, Vol.16 (12), p.2048-2054</ispartof><rights>2017 © 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.</rights><rights>2017 by The American Society for Biochemistry and Molecular Biology, Inc.</rights><rights>Copyright American Society for Biochemistry and Molecular Biology Dec 2017</rights><rights>2017 by The American Society for Biochemistry and Molecular Biology, Inc. 2017 The American Society for Biochemistry and Molecular Biology, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-7da32f13bef5ebc35a87ced7032c1825b78ab2d3d82332c9bae36c5f50709edc3</citedby><cites>FETCH-LOGICAL-c522t-7da32f13bef5ebc35a87ced7032c1825b78ab2d3d82332c9bae36c5f50709edc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724170/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724170/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28954815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bergeron, John J.M.</creatorcontrib><creatorcontrib>Au, Catherine E.</creatorcontrib><creatorcontrib>Thomas, David Y.</creatorcontrib><creatorcontrib>Hermo, Louis</creatorcontrib><title>Proteomics Identifies Golgi phosphoprotein 3 (GOLPH3) with A Link Between Golgi Structure, Cancer, DNA Damage and Protection from Cell Death</title><title>Molecular & cellular proteomics</title><addtitle>Mol Cell Proteomics</addtitle><description>GOLPH3 is the first example of a Golgi resident oncogene protein. It was independently identified in multiple screens; first in proteomic-based screens as a resident protein of the Golgi apparatus, and second as an oncogene product in a screen for genes amplified in cancer. 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| subjects | Animals Cancer Cell Death Deoxyribonucleic acid DNA DNA Damage DNA structure Gene Amplification Golgi apparatus Golgi Apparatus - chemistry Golgi Apparatus - metabolism Humans Liver - metabolism Membrane Proteins - chemistry Membrane Proteins - metabolism Mini Review Models, Molecular Neoplasms - metabolism Phosphates Phosphatidylinositol Phosphates - metabolism Phospholipids Protein Structure, Tertiary Proteins Proteomics Proteomics - methods Screens Structural damage |
| title | Proteomics Identifies Golgi phosphoprotein 3 (GOLPH3) with A Link Between Golgi Structure, Cancer, DNA Damage and Protection from Cell Death |
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