Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM

Ataxia-telangiectasia mutated (ATM) regulates the DNA damage response as well as DNA double-strand break repair through homologous recombination. Here we show that ATM is hyperactive when the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is chemically inhibited or when the DNA-PKcs ge...

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Veröffentlicht in:	Molecular cell 2017-01, Vol.65 (1), p.91-104
Hauptverfasser:	Zhou, Yi, Lee, Ji-Hoon, Jiang, Wenxia, Crowe, Jennie L., Zha, Shan, Paull, Tanya T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - metabolism ATM Cell Cycle Cell Line, Tumor Cell Proliferation cell-cycle checkpoint DNA Breaks, Double-Stranded DNA Repair DNA-Activated Protein Kinase - genetics DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-PKcs Embryonic Stem Cells - enzymology Genotype HEK293 Cells Humans Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Oxidative Stress Phenotype Phosphorylation protein kinase RNA Interference Signal Transduction Time Factors Transfection
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