Dynamic landscape and regulation of RNA editing in mammals

Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2. Genetic effects on gene expression across human tissues The GTEx (G...

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Veröffentlicht in:	Nature (London) 2017-10, Vol.550 (7675), p.249-254
Hauptverfasser:	Tan, Meng How, Li, Qin, Shanmugam, Raghuvaran, Piskol, Robert, Kohler, Jennefer, Young, Amy N., Liu, Kaiwen Ivy, Zhang, Rui, Ramaswami, Gokul, Ariyoshi, Kentaro, Gupte, Ankita, Keegan, Liam P., George, Cyril X., Ramu, Avinash, Huang, Ni, Pollina, Elizabeth A., Leeman, Dena S., Rustighi, Alessandra, Goh, Y. P. Sharon, Chawla, Ajay, Del Sal, Giannino, Peltz, Gary, Brunet, Anne, Conrad, Donald F., Samuel, Charles E., O’Connell, Mary A., Walkley, Carl R., Nishikura, Kazuko, Li, Jin Billy
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/39 38/91 631/208/200 631/208/212/2019 631/337/1645/1944 Adenosine Adenosine Deaminase - genetics Adenosine Deaminase - metabolism Animals Brain Enzymes Female Gene expression Genetic aspects Genetic regulation Genetic research Genomes Genotype HEK293 Cells Humanities and Social Sciences Humans letter Male Mammals Mice multidisciplinary Muscles Muscles - metabolism Musculoskeletal system Nuclear Proteins - metabolism Nucleotides Organ Specificity - genetics Post-transcription Primates - genetics Principal components analysis Proteins Proteolysis Ribonucleic acid RNA RNA editing RNA Editing - genetics RNA processing RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Science Spatio-Temporal Analysis Species Specificity Tissues Transcription Transcriptome - genetics
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