Exosome is a mechanism of intercellular drug transfer: Application of quantitative pharmacology

Exosomes are small membrane vesicles (30–100nm in diameter) secreted by cells into extracellular space. The present study evaluated the effect of chemotherapeutic agents on exosome production and/or release, and quantified the contribution of exosomes to intercellular drug transfer and pharmacodynam...

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Veröffentlicht in:	Journal of controlled release 2017-12, Vol.268, p.147-158
Hauptverfasser:	Wang, Jin, Yeung, Bertrand Z., Cui, Minjian, Peer, Cody J., Lu, Ze, Figg, William D., Guillaume Wientjes, M., Woo, Sukyung, Au, Jessie L.-S.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Antineoplastic Agents - pharmacology Biological Transport breast neoplasms breasts Cell Line, Tumor Cell Survival - drug effects Chemoresistance culture media cytotoxicity developmental stages doxorubicin Doxorubicin - pharmacology drug therapy enzyme activity Exocytosis Exosome exosomes Exosomes - metabolism extracellular space Humans Intercellular drug transfer metastasis Models, Biological neoplasm cells ovarian neoplasms P-glycoproteins paclitaxel Paclitaxel - pharmacology pharmacodynamics pharmacokinetics Pharmacology Quantitative pharmacology simulation models
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