Mouse schwann cells need both NRG1 and cyclic AMP to myelinate

Genetically modified mice have been a major source of information about the molecular control of Schwann‐cell myelin formation, and the role of β‐neuregulin 1 (NRG1) in this process in vivo. In vitro, on the other hand, Schwann cells from rats have been used in most analyses of the signaling pathway...

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Veröffentlicht in:	Glia 2011-05, Vol.59 (5), p.720-733
Hauptverfasser:	Arthur-Farraj, Peter, Wanek, Katharina, Hantke, Janina, Davis, Catherine M., Jayakar, Anuj, Parkinson, David B., Mirsky, Rhona, Jessen, Kristján R.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenovirus Analysis of Variance Animals Blotting, Western Cell culture Cell proliferation Cells, Cultured CREB Cyclic AMP Cyclic AMP - metabolism Cyclic AMP - pharmacology Data processing Differentiation Immunohistochemistry In Situ Hybridization Krox-20 protein Krox-20/Egr2 Mice Myelin P0 protein Myelin P0 Protein - metabolism Myelin Sheath - drug effects Myelin Sheath - metabolism Myelination neuregulin Neuregulin-1 - metabolism Neuregulin-1 - pharmacology proliferation protein kinase A Rats Rats, Sprague-Dawley Regulatory sequences Reverse Transcriptase Polymerase Chain Reaction Schwann cells Schwann Cells - cytology Schwann Cells - drug effects Schwann Cells - metabolism Sciatic Nerve - cytology Sciatic Nerve - drug effects Sciatic Nerve - metabolism Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Transcription factors
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