Viability testing and transplantation of marginal livers (VITTAL) using normothermic machine perfusion: study protocol for an open-label, non-randomised, prospective, single-arm trial

IntroductionThe use of marginal or extended criteria donor livers is increasing. These organs carry a greater risk of initial dysfunction and early failure, as well as inferior long-term outcomes. As such, many are rejected due to a perceived risk of use and use varies widely between centres. Ex sit...

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Veröffentlicht in:	BMJ open 2017-11, Vol.7 (11), p.e017733-e017733
Hauptverfasser:	Laing, Richard W, Mergental, Hynek, Yap, Christina, Kirkham, Amanda, Whilku, Manpreet, Barton, Darren, Curbishley, Stuart, Boteon, Yuri L, Neil, Desley A, Hübscher, Stefan G, Perera, M Thamara P R, Muiesan, Paolo, Isaac, John, Roberts, Keith J, Cilliers, Hentie, Afford, Simon C, Mirza, Darius F
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Blood & organ donations Clinical trials Evidence-based medicine Feasibility Studies Humans Liver - metabolism Liver cancer Liver diseases Liver Transplantation Mortality Non-Randomized Controlled Trials as Topic Organ Preservation - methods Perfusion - methods Practice Guidelines as Topic Prospective Studies Surgery Time Factors Tissue and Organ Procurement - methods Tissue and Organ Procurement - standards Tissue Survival Transplant Recipients Transplants & implants
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