Diabetic Microvascular Disease: An Endocrine Society Scientific Statement
Abstract Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pat...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2017-12, Vol.102 (12), p.4343-4410 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Barrett, Eugene J Liu, Zhenqi Khamaisi, Mogher King, George L Klein, Ronald Klein, Barbara E K Hughes, Timothy M Craft, Suzanne Freedman, Barry I Bowden, Donald W Vinik, Aaron I Casellini, Carolina M |
| description | Abstract
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle. Despite extensive and intensive research, it is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes. Hopefully, by understanding and building on current research findings, we will discover new approaches for prevention and treatment that will be effective for future generations.
This scientific statement reviews and discusses the microvascular complications of diabetes on an organ-by-organ basis. |
| doi_str_mv | 10.1210/jc.2017-01922 |
| format | Article |
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Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle. Despite extensive and intensive research, it is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes. Hopefully, by understanding and building on current research findings, we will discover new approaches for prevention and treatment that will be effective for future generations.
This scientific statement reviews and discusses the microvascular complications of diabetes on an organ-by-organ basis.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2017-01922</identifier><identifier>PMID: 29126250</identifier><language>eng</language><publisher>Washington, DC: Endocrine Society</publisher><subject>Adipose tissue ; Cerebrovascular Disorders - epidemiology ; Cerebrovascular Disorders - metabolism ; Cerebrovascular Disorders - pathology ; Complications ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 2 - complications ; Diabetic Angiopathies - epidemiology ; Diabetic Angiopathies - metabolism ; Diabetic Angiopathies - pathology ; Diabetic Nephropathies - epidemiology ; Diabetic Nephropathies - metabolism ; Diabetic Nephropathies - pathology ; Diabetic Retinopathy - epidemiology ; Diabetic Retinopathy - metabolism ; Diabetic Retinopathy - pathology ; Eye injuries ; Heart diseases ; Humans ; Insulin ; Insulin resistance ; Microvasculature ; Muscles ; Nervous system ; Organs ; Peripheral nervous system ; Quality of Life ; Scientific Statement ; Skeletal muscle ; Skin</subject><ispartof>The journal of clinical endocrinology and metabolism, 2017-12, Vol.102 (12), p.4343-4410</ispartof><rights>Copyright © 2017 Endocrine Society 2017</rights><rights>Copyright © Oxford University Press 2015</rights><rights>Copyright © 2017 Endocrine Society.</rights><rights>Copyright © 2017 Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5562-925e29493f311ddcbe9f0135dbc2443102c4d0c44dea9d78d62677f83de05a8d3</citedby><cites>FETCH-LOGICAL-c5562-925e29493f311ddcbe9f0135dbc2443102c4d0c44dea9d78d62677f83de05a8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2023882919?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,776,780,881,21367,27901,27902,33721,33722,43781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29126250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barrett, Eugene J</creatorcontrib><creatorcontrib>Liu, Zhenqi</creatorcontrib><creatorcontrib>Khamaisi, Mogher</creatorcontrib><creatorcontrib>King, George L</creatorcontrib><creatorcontrib>Klein, Ronald</creatorcontrib><creatorcontrib>Klein, Barbara E K</creatorcontrib><creatorcontrib>Hughes, Timothy M</creatorcontrib><creatorcontrib>Craft, Suzanne</creatorcontrib><creatorcontrib>Freedman, Barry I</creatorcontrib><creatorcontrib>Bowden, Donald W</creatorcontrib><creatorcontrib>Vinik, Aaron I</creatorcontrib><creatorcontrib>Casellini, Carolina M</creatorcontrib><title>Diabetic Microvascular Disease: An Endocrine Society Scientific Statement</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle. Despite extensive and intensive research, it is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes. Hopefully, by understanding and building on current research findings, we will discover new approaches for prevention and treatment that will be effective for future generations.
This scientific statement reviews and discusses the microvascular complications of diabetes on an organ-by-organ basis.</description><subject>Adipose tissue</subject><subject>Cerebrovascular Disorders - epidemiology</subject><subject>Cerebrovascular Disorders - metabolism</subject><subject>Cerebrovascular Disorders - pathology</subject><subject>Complications</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Angiopathies - epidemiology</subject><subject>Diabetic Angiopathies - metabolism</subject><subject>Diabetic Angiopathies - pathology</subject><subject>Diabetic Nephropathies - epidemiology</subject><subject>Diabetic Nephropathies - metabolism</subject><subject>Diabetic Nephropathies - pathology</subject><subject>Diabetic Retinopathy - epidemiology</subject><subject>Diabetic Retinopathy - metabolism</subject><subject>Diabetic Retinopathy - pathology</subject><subject>Eye injuries</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Microvasculature</subject><subject>Muscles</subject><subject>Nervous system</subject><subject>Organs</subject><subject>Peripheral nervous system</subject><subject>Quality of Life</subject><subject>Scientific Statement</subject><subject>Skeletal muscle</subject><subject>Skin</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1v1DAQxS0EotvCkSuKxIVLij2245gDUtVvqYjDgsTN8toT1ks2XuykVf_7ut1tBZU4jUbz8xu_eYS8Y_SQAaOfVu4QKFM1ZRrgBZkxLWStmFYvyYxSYLVW8HOP7Oe8opQJIflrsgeaQQOSzsjlSbALHIOrvgaX4rXNbuptqk5CRpvxc3U0VKeDjy6FAat5dAHH22peyjCGrjybj3bEdenekFed7TO-3dUD8uPs9PvxRX317fzy-OiqdlI2UGuQCFpo3nHGvHcL1B1lXPqFAyE4o-CEp04Ij1Z71foGGqW6lnuk0raeH5AvW93NtFijd2V1sr3ZpLC26dZEG8y_kyEsza94baRibaNVEfi4E0jxz4R5NOuQHfa9HTBO2TDdcGh0o2lBPzxDV3FKQ7FngAJv23JIXah6S5UD5pywe_oMo-Y-JLNy5j4k8xBS4d__7eCJfkylAGwL3MR-xJR_99MNJrNE24_L56L1o-jOVZw2_9u_Q-8AFw2ouQ</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Barrett, Eugene J</creator><creator>Liu, Zhenqi</creator><creator>Khamaisi, Mogher</creator><creator>King, George L</creator><creator>Klein, Ronald</creator><creator>Klein, Barbara E K</creator><creator>Hughes, Timothy M</creator><creator>Craft, Suzanne</creator><creator>Freedman, Barry I</creator><creator>Bowden, Donald W</creator><creator>Vinik, Aaron I</creator><creator>Casellini, Carolina M</creator><general>Endocrine Society</general><general>Copyright Oxford University Press</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171201</creationdate><title>Diabetic Microvascular Disease: An Endocrine Society Scientific Statement</title><author>Barrett, Eugene J ; Liu, Zhenqi ; Khamaisi, Mogher ; King, George L ; Klein, Ronald ; Klein, Barbara E K ; Hughes, Timothy M ; Craft, Suzanne ; Freedman, Barry I ; Bowden, Donald W ; Vinik, Aaron I ; Casellini, Carolina M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5562-925e29493f311ddcbe9f0135dbc2443102c4d0c44dea9d78d62677f83de05a8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipose tissue</topic><topic>Cerebrovascular Disorders - epidemiology</topic><topic>Cerebrovascular Disorders - metabolism</topic><topic>Cerebrovascular Disorders - pathology</topic><topic>Complications</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic Angiopathies - epidemiology</topic><topic>Diabetic Angiopathies - metabolism</topic><topic>Diabetic Angiopathies - pathology</topic><topic>Diabetic Nephropathies - epidemiology</topic><topic>Diabetic Nephropathies - metabolism</topic><topic>Diabetic Nephropathies - pathology</topic><topic>Diabetic Retinopathy - epidemiology</topic><topic>Diabetic Retinopathy - metabolism</topic><topic>Diabetic Retinopathy - pathology</topic><topic>Eye injuries</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Microvasculature</topic><topic>Muscles</topic><topic>Nervous system</topic><topic>Organs</topic><topic>Peripheral nervous system</topic><topic>Quality of Life</topic><topic>Scientific Statement</topic><topic>Skeletal muscle</topic><topic>Skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barrett, Eugene J</creatorcontrib><creatorcontrib>Liu, Zhenqi</creatorcontrib><creatorcontrib>Khamaisi, Mogher</creatorcontrib><creatorcontrib>King, George L</creatorcontrib><creatorcontrib>Klein, Ronald</creatorcontrib><creatorcontrib>Klein, Barbara E K</creatorcontrib><creatorcontrib>Hughes, Timothy M</creatorcontrib><creatorcontrib>Craft, Suzanne</creatorcontrib><creatorcontrib>Freedman, Barry I</creatorcontrib><creatorcontrib>Bowden, Donald W</creatorcontrib><creatorcontrib>Vinik, Aaron I</creatorcontrib><creatorcontrib>Casellini, Carolina M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barrett, Eugene J</au><au>Liu, Zhenqi</au><au>Khamaisi, Mogher</au><au>King, George L</au><au>Klein, Ronald</au><au>Klein, Barbara E K</au><au>Hughes, Timothy M</au><au>Craft, Suzanne</au><au>Freedman, Barry I</au><au>Bowden, Donald W</au><au>Vinik, Aaron I</au><au>Casellini, Carolina M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetic Microvascular Disease: An Endocrine Society Scientific Statement</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>102</volume><issue>12</issue><spage>4343</spage><epage>4410</epage><pages>4343-4410</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle. Despite extensive and intensive research, it is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes. Hopefully, by understanding and building on current research findings, we will discover new approaches for prevention and treatment that will be effective for future generations.
This scientific statement reviews and discusses the microvascular complications of diabetes on an organ-by-organ basis.</abstract><cop>Washington, DC</cop><pub>Endocrine Society</pub><pmid>29126250</pmid><doi>10.1210/jc.2017-01922</doi><tpages>68</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete; ProQuest Central |
| subjects | Adipose tissue Cerebrovascular Disorders - epidemiology Cerebrovascular Disorders - metabolism Cerebrovascular Disorders - pathology Complications Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 2 - complications Diabetic Angiopathies - epidemiology Diabetic Angiopathies - metabolism Diabetic Angiopathies - pathology Diabetic Nephropathies - epidemiology Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Retinopathy - epidemiology Diabetic Retinopathy - metabolism Diabetic Retinopathy - pathology Eye injuries Heart diseases Humans Insulin Insulin resistance Microvasculature Muscles Nervous system Organs Peripheral nervous system Quality of Life Scientific Statement Skeletal muscle Skin |
| title | Diabetic Microvascular Disease: An Endocrine Society Scientific Statement |
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