Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making

Increased activity of dopamine receptor type-2 (D2R)-expressing cells in the nucleus accumbens of rats during a ‘decision’ period reflects a ‘loss’ outcome of the previous decision and predicts a subsequent safe choice; by artificially increasing the activity of D2R neurons during the decision perio...

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Veröffentlicht in:	Nature (London) 2016-03, Vol.531 (7596), p.642-646
Hauptverfasser:	Zalocusky, Kelly A., Ramakrishnan, Charu, Lerner, Talia N., Davidson, Thomas J., Knutson, Brian, Deisseroth, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2649/1662 631/443/376 Animals Cellular signal transduction Choice Behavior Decision Making Dopamine Dopamine receptors Expected values Humanities and Social Sciences Humans Individuality letter Male Models, Animal Models, Neurological Models, Psychological multidisciplinary Neurological research Neurons Neurons - metabolism Nucleus accumbens Nucleus Accumbens - cytology Nucleus Accumbens - metabolism Physiological aspects Rats Rats, Long-Evans Rattus Receptors, Dopamine D2 - metabolism Reward Risk aversion Risk Management Risk-taking (Psychology) Science Signal Transduction Uncertainty
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