Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication

Trifluridine/tipiracil (TFTD, TAS-102) is an orally administrated anti-cancer drug with efficacy validated for patients with metastatic colorectal cancer (mCRC). Trifluridine (FTD) is an active cytotoxic component of TFTD and mediates the anticancer effect via its incorporation into DNA. However, it...

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Veröffentlicht in:	Scientific reports 2017-12, Vol.7 (1), p.16969-8, Article 16969
Hauptverfasser:	Nakanishi, Ryota, Kitao, Hiroyuki, Kiniwa, Mamoru, Morodomi, Yosuke, Iimori, Makoto, Kurashige, Junji, Sugiyama, Masahiko, Nakashima, Yuichiro, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 692/4020/1503/1504/1885 692/4028/67/1059/99 Antiviral drugs Bone marrow Colorectal cancer Colorectal carcinoma Cytotoxicity Deoxyribonucleic acid DNA Drugs Frontotemporal dementia Humanities and Social Sciences Incorporation Leukocytes (mononuclear) Metastases multidisciplinary Peripheral blood mononuclear cells Science Science (multidisciplinary) Spleen
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