New Hybrid Hydrazinyl Thiazole Substituted Chromones: As Potential α-Amylase Inhibitors and Radical (DPPH & ABTS) Scavengers

Current research is based on the identification of novel inhibitors of α -amylase enzyme. For that purpose, new hybrid molecules of hydrazinyl thiazole substituted chromones 5 – 27 were synthesized by multi-step reaction and fully characterized by various spectroscopic techniques such as EI-MS, HREI...

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Veröffentlicht in:	Scientific reports 2017-12, Vol.7 (1), p.16980-17, Article 16980
Hauptverfasser:	Salar, Uzma, Khan, Khalid Mohammed, Chigurupati, Sridevi, Taha, Muhammad, Wadood, Abdul, Vijayabalan, Shantini, Ghufran, Mehreen, Perveen, Shahnaz
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 631/92/606 639/638/92/606 Acarbose alpha-Amylases - antagonists & inhibitors Animals Antifungal agents Ascorbic acid Biphenyl Compounds Chromones - chemistry Chromones - pharmacology Computer Simulation Cytotoxicity Drug Evaluation, Preclinical - methods Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Humanities and Social Sciences Intermediates Mass Spectrometry Mice Molecular Docking Simulation Molecular Structure multidisciplinary NIH 3T3 Cells NMR Nuclear magnetic resonance Picrates Science Science (multidisciplinary) Stereochemistry Structure-Activity Relationship Thiazoles - chemistry α-Amylase
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