HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia

Philadelphia chromosome-positive (Ph+) B-cell precursor acute lymphoblastic leukemia (ALL) expressing BCR-ABL1 oncoprotein is a major subclass of ALL with poor prognosis. BCR-ABL1-expressing leukemic cells are highly dependent on double-strand break (DSB) repair signals for their survival. Here we r...

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Veröffentlicht in:	Leukemia 2018-01, Vol.32 (1), p.49-60
Hauptverfasser:	Tharkar-Promod, S, Johnson, D P, Bennett, S E, Dennis, E M, Banowsky, B G, Jones, S S, Shearstone, J R, Quayle, S N, Min, C, Jarpe, M, Mosbruger, T, Pomicter, A D, Miles, R R, Chen, W Y, Bhalla, K N, Zweidler-McKay, P A, Shrieve, D C, Deininger, M W, Chandrasekharan, M B, Bhaskara, S
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 13/51 38/1 38/15 38/91 631/67/1990 64/60 692/699/1541 82/51 82/58 82/80 Acute lymphoblastic leukemia Acute lymphocytic leukemia Addictions Animal models Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology BCR-ABL protein Cancer Research Cell Line, Tumor Chemotherapy Chromatin Critical Care Medicine Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded - drug effects DNA damage DNA repair DNA Repair - drug effects Dosage and administration Double-strand break repair Doxorubicin Doxorubicin - administration & dosage Drug therapy Fusion Proteins, bcr-abl - metabolism Gene silencing Genetic aspects Hematology Histone Deacetylase 1 - antagonists & inhibitors Histone Deacetylase 2 - antagonists & inhibitors Humans Inhibition Inhibitors Intensive Internal Medicine Leukemia Lymphatic leukemia Lymphocytes B Mass spectrometry Mass spectroscopy Medical prognosis Medicine Medicine & Public Health Mice MRE11 protein Oncology Original original-article Philadelphia chromosome Philadelphia Chromosome - drug effects Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Proteomes Repair Signaling Xenografts
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