ABC294640, A Novel Sphingosine Kinase 2 Inhibitor, Induces Oncogenic Virus-Infected Cell Autophagic Death and Represses Tumor Growth

Kaposi sarcoma-associated herpes virus (KSHV) is the etiologic agent of several malignancies, including Kaposi sarcoma and primary effusion lymphoma (PEL), which preferentially arise in HIV patients and lack effective treatment. Sphingosine kinase 2 (SphK2) is a key factor within sphingolipid metabo...

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Veröffentlicht in:	Molecular cancer therapeutics 2017-12, Vol.16 (12), p.2724-2734
Hauptverfasser:	Dai, Lu, Bai, Aiping, Smith, Charles D, Rodriguez, Paulo C, Yu, Fangyou, Qin, Zhiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - pharmacology Adamantane - therapeutic use Animals Apoptosis Autophagy Cell cycle Cell death Cell Proliferation Cellular stress response Death Effusion EGR-1 protein Endothelial cells Enzyme inhibitors Etiology Herpesvirus 8, Human - pathogenicity HIV Human immunodeficiency virus Humans Inhibitors Kinases Lipid metabolism Lymphoma Metabolism Mice Microscopy, Electron Mortality Phosphates Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Primary effusion lymphoma Pyridines - pharmacology Pyridines - therapeutic use Sarcoma Sphingosine 1-phosphate Sphingosine kinase Tumor cells Tumor viruses Viruses
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