Plasminogen activator inhibitor‐1 regulates the vascular expression of vitronectin

Essentials Vitronectin (VN) is produced by smooth muscle cells (SMCs) and promotes neointima formation. We studied the regulation of vascular VN expression by plasminogen activator inhibitor‐1 (PAI‐1). PAI‐1 stimulates VN gene expression in SMCs by binding LDL receptor‐related protein 1. Stimulation...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2017-12, Vol.15 (12), p.2451-2460
Hauptverfasser:	Luo, M., Ji, Y., Luo, Y., Li, R., Fay, W. P., Wu, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteriosclerosis Autocrine signalling Carotid artery Gene expression Homeostasis Hyperplasia Kinases Low density lipoprotein muscle, smooth, vascular Plasminogen activator inhibitors plasminogen inactivators Rodents serine proteinase inhibitors siRNA Smooth muscle Surgery Transgenic mice Vascular diseases vascular remodeling Vitronectin
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