Phosphorylation promotes activation-induced cytidine deaminase activity at the Myc oncogene

Activation-induced cytidine deaminase (AID) is a mutator enzyme that targets immunoglobulin (Ig) genes to initiate antibody somatic hypermutation (SHM) and class switch recombination (CSR). Off-target AID association also occurs, which causes oncogenic mutations and chromosome rearrangements. Howeve...

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Veröffentlicht in:	The Journal of experimental medicine 2017-12, Vol.214 (12), p.3543-3552
Hauptverfasser:	Mu, Yunxiang, Zelazowska, Monika A, McBride, Kevin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation-induced cytidine deaminase Chromatin Chromosome rearrangements Chromosome translocations Class switching Cytidine deaminase Deoxyribonucleic acid DNA DNA damage Genes Immunoglobulins Lesions Lithium Molecular modelling Mutation Myc protein Oncogenes Pharmacology Phosphorylation Recombination Somatic hypermutation Translocation
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