Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex

The HerA-NurA helicase-nuclease complex cooperates with Mre11 and Rad50 to coordinate the repair of double-stranded DNA breaks. Little is known, however, about the assembly mechanism and activation of the HerA-NurA. By combining hybrid mass spectrometry with cryo-EM, computational and biochemical da...

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Veröffentlicht in:	Nucleic acids research 2017-11, Vol.45 (20), p.12025-12038
Hauptverfasser:	Ahdash, Zainab, Lau, Andy M, Byrne, Robert Thomas, Lammens, Katja, Stüetzer, Alexandra, Urlaub, Henning, Booth, Paula J, Reading, Eamonn, Hopfner, Karl-Peter, Politis, Argyris
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Archaeal Proteins - chemistry Archaeal Proteins - genetics Archaeal Proteins - metabolism Binding Sites - genetics Deoxyribonucleases - chemistry Deoxyribonucleases - genetics Deoxyribonucleases - metabolism DNA Breaks, Double-Stranded DNA Helicases - chemistry DNA Helicases - genetics DNA Helicases - metabolism DNA Repair DNA, Archaeal - chemistry DNA, Archaeal - genetics DNA, Archaeal - metabolism Models, Molecular Nucleic Acid Conformation Protein Binding Protein Domains Protein Multimerization Structural Biology Sulfolobus solfataricus - enzymology Sulfolobus solfataricus - genetics Sulfolobus solfataricus - metabolism
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