Gα12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner

Background and Purpose PI3K‐dependent activation of Rho kinase (ROCK) is necessary for agonist‐induced human airway smooth muscle cell (HASMC) contraction, and inhibition of PI3K promotes bronchodilation of human small airways. The mechanisms driving agonist‐mediated PI3K/ROCK axis activation, howev...

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Veröffentlicht in:	British journal of pharmacology 2017-12, Vol.174 (23), p.4383-4395
Hauptverfasser:	Yoo, Edwin J, Cao, Gaoyuan, Koziol‐White, Cynthia J, Ojiaku, Christie A, Sunder, Krishna, Jude, Joseph A, Michael, James V, Lam, Hong, Pushkarsky, Ivan, Damoiseaux, Robert, Di Carlo, Dino, Ahn, Kwangmi, An, Steven S, Penn, Raymond B, Panettieri, Reynold A
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper Research Papers
Online-Zugang:	Volltext
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