Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome
Purpose Proteomic studies suggest an association between haptoglobin (Hp) and polycystic ovary syndrome (PCOS). Hp is a classic inflammatory marker and binds to the intravascular hemoglobin, avoiding the oxidative damages that can be caused by free hemoglobin. Inflammation and oxidative stress are i...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2017-12, Vol.34 (12), p.1691-1698 |
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| creator | Carvalho, Laura M. L. Ferreira, Cláudia N. de Oliveira, Daisy K. D. Rodrigues, Kathryna F. Duarte, Rita C. F. Teixeira, Márcia F. A. Xavier, Luana B. Candido, Ana Lúcia Reis, Fernando M. Silva, Ieda F. O. Campos, Fernanda M. F. Gomes, Karina B. |
| description | Purpose
Proteomic studies suggest an association between haptoglobin (Hp) and polycystic ovary syndrome (PCOS). Hp is a classic inflammatory marker and binds to the intravascular hemoglobin, avoiding the oxidative damages that can be caused by free hemoglobin. Inflammation and oxidative stress are important in the pathogenesis of the PCOS, one of the most frequent metabolic diseases in women.
Methods
To validate these proteomic studies, we developed a controlled cross-sectional study that aimed to evaluate the Hp levels and allelic and genotypic frequencies of Hp1-Hp2 polymorphism in Brazilian women with PCOS. We also investigated the correlation between Hp levels and several important parameters in PCOS as follows: body mass index (BMI), waist circumference (WC), fasting glucose, post-prandial glucose, homeostatic model assessment (HOMA), lipid accumulation product (LAP), C-reactive protein (CRP), and metabolization test of tetrazolium salts (MTTs—serum antioxidant capacity).
Results
Plasma Hp levels were higher in the PCOS group than in controls [8.20 (4.04) g/L; 7.98 (3.31) g/L;
p
= 0.018]. No significant difference was observed in the frequency of Hp1-Hp2 genotypes under additive, recessive, or dominant model of inheritance between the PCOS and the control groups. Plasma Hp levels did not differ according to the genotype. However, plasma Hp showed a negative correlation with MTT (
r
= − 0.383;
p
= 0.028), as well as a positive correlation with CRP (
r
= 0.361;
p
= 0.014) in the PCOS group.
Conclusion
Hp1-Hp2 polymorphism is not associated with PCOS but plasma Hp could be a potential biomarker for PCOS and its complications. |
| doi_str_mv | 10.1007/s10815-017-1030-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5714822</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1972157514</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-365a94f465f1f424b3c35a57fae49f86e0d2a6eb2601b8817e08f73b6b3a5e373</originalsourceid><addsrcrecordid>eNp1kUtLxDAUhYMovn-AGwm4NXrzatKNIIM6guBG1yHtpDOVtqlJZmT-vdFR0YWrBO53zj3cg9AJhQsKoC4jBU0lAaoIBQ6Eb6F9KhUninPYzn-QmoAo9B46iPEFAErN-C7aY7rM-lLuIzO1Y_LzzlftgDu3cl08x9Uy4cEnPB0pmY4Mj75b9z6Mizb259gGh22Mvm5tcjP81qbFJ1GvY2pr7Fc2rHFcD7Pge3eEdhrbRXf89R6i59ubp8mUPDze3U-uH0gtFCTCC2lL0YhCNrQRTFS85tJK1VgnykYXDmbMFq5iBdBKa6oc6Ebxqqi4lY4rfoiuNr7jsurdrHZDCrYzY2j7HMd425q_k6FdmLlfGamo0Ixlg7Mvg-Bfly4m8-KXYciZDS0Vy2eVVGSKbqg6-BiDa342UDAfnZhNJyZ3Yj46MTxrTn9H-1F8l5ABtgFiHg1zF36t_tf1HRQ7mIY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1972157514</pqid></control><display><type>article</type><title>Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome</title><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Carvalho, Laura M. L. ; Ferreira, Cláudia N. ; de Oliveira, Daisy K. D. ; Rodrigues, Kathryna F. ; Duarte, Rita C. F. ; Teixeira, Márcia F. A. ; Xavier, Luana B. ; Candido, Ana Lúcia ; Reis, Fernando M. ; Silva, Ieda F. O. ; Campos, Fernanda M. F. ; Gomes, Karina B.</creator><creatorcontrib>Carvalho, Laura M. L. ; Ferreira, Cláudia N. ; de Oliveira, Daisy K. D. ; Rodrigues, Kathryna F. ; Duarte, Rita C. F. ; Teixeira, Márcia F. A. ; Xavier, Luana B. ; Candido, Ana Lúcia ; Reis, Fernando M. ; Silva, Ieda F. O. ; Campos, Fernanda M. F. ; Gomes, Karina B.</creatorcontrib><description>Purpose
Proteomic studies suggest an association between haptoglobin (Hp) and polycystic ovary syndrome (PCOS). Hp is a classic inflammatory marker and binds to the intravascular hemoglobin, avoiding the oxidative damages that can be caused by free hemoglobin. Inflammation and oxidative stress are important in the pathogenesis of the PCOS, one of the most frequent metabolic diseases in women.
Methods
To validate these proteomic studies, we developed a controlled cross-sectional study that aimed to evaluate the Hp levels and allelic and genotypic frequencies of Hp1-Hp2 polymorphism in Brazilian women with PCOS. We also investigated the correlation between Hp levels and several important parameters in PCOS as follows: body mass index (BMI), waist circumference (WC), fasting glucose, post-prandial glucose, homeostatic model assessment (HOMA), lipid accumulation product (LAP), C-reactive protein (CRP), and metabolization test of tetrazolium salts (MTTs—serum antioxidant capacity).
Results
Plasma Hp levels were higher in the PCOS group than in controls [8.20 (4.04) g/L; 7.98 (3.31) g/L;
p
= 0.018]. No significant difference was observed in the frequency of Hp1-Hp2 genotypes under additive, recessive, or dominant model of inheritance between the PCOS and the control groups. Plasma Hp levels did not differ according to the genotype. However, plasma Hp showed a negative correlation with MTT (
r
= − 0.383;
p
= 0.028), as well as a positive correlation with CRP (
r
= 0.361;
p
= 0.014) in the PCOS group.
Conclusion
Hp1-Hp2 polymorphism is not associated with PCOS but plasma Hp could be a potential biomarker for PCOS and its complications.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-017-1030-3</identifier><identifier>PMID: 28900795</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antioxidants ; Body mass ; Body mass index ; C-reactive protein ; Complications ; Gene polymorphism ; Genotypes ; Glucose ; Gynecology ; Haptoglobin ; Hemoglobin ; Heredity ; Human Genetics ; Inflammation ; Medicine ; Medicine & Public Health ; Metabolic disorders ; Oxidative stress ; Polycystic ovary syndrome ; Reproductive Medicine ; Reproductive Physiology and Disease ; Salts</subject><ispartof>Journal of assisted reproduction and genetics, 2017-12, Vol.34 (12), p.1691-1698</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>Journal of Assisted Reproduction and Genetics is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-365a94f465f1f424b3c35a57fae49f86e0d2a6eb2601b8817e08f73b6b3a5e373</citedby><cites>FETCH-LOGICAL-c470t-365a94f465f1f424b3c35a57fae49f86e0d2a6eb2601b8817e08f73b6b3a5e373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714822/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714822/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,41469,42538,51300,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28900795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carvalho, Laura M. L.</creatorcontrib><creatorcontrib>Ferreira, Cláudia N.</creatorcontrib><creatorcontrib>de Oliveira, Daisy K. D.</creatorcontrib><creatorcontrib>Rodrigues, Kathryna F.</creatorcontrib><creatorcontrib>Duarte, Rita C. F.</creatorcontrib><creatorcontrib>Teixeira, Márcia F. A.</creatorcontrib><creatorcontrib>Xavier, Luana B.</creatorcontrib><creatorcontrib>Candido, Ana Lúcia</creatorcontrib><creatorcontrib>Reis, Fernando M.</creatorcontrib><creatorcontrib>Silva, Ieda F. O.</creatorcontrib><creatorcontrib>Campos, Fernanda M. F.</creatorcontrib><creatorcontrib>Gomes, Karina B.</creatorcontrib><title>Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
Proteomic studies suggest an association between haptoglobin (Hp) and polycystic ovary syndrome (PCOS). Hp is a classic inflammatory marker and binds to the intravascular hemoglobin, avoiding the oxidative damages that can be caused by free hemoglobin. Inflammation and oxidative stress are important in the pathogenesis of the PCOS, one of the most frequent metabolic diseases in women.
Methods
To validate these proteomic studies, we developed a controlled cross-sectional study that aimed to evaluate the Hp levels and allelic and genotypic frequencies of Hp1-Hp2 polymorphism in Brazilian women with PCOS. We also investigated the correlation between Hp levels and several important parameters in PCOS as follows: body mass index (BMI), waist circumference (WC), fasting glucose, post-prandial glucose, homeostatic model assessment (HOMA), lipid accumulation product (LAP), C-reactive protein (CRP), and metabolization test of tetrazolium salts (MTTs—serum antioxidant capacity).
Results
Plasma Hp levels were higher in the PCOS group than in controls [8.20 (4.04) g/L; 7.98 (3.31) g/L;
p
= 0.018]. No significant difference was observed in the frequency of Hp1-Hp2 genotypes under additive, recessive, or dominant model of inheritance between the PCOS and the control groups. Plasma Hp levels did not differ according to the genotype. However, plasma Hp showed a negative correlation with MTT (
r
= − 0.383;
p
= 0.028), as well as a positive correlation with CRP (
r
= 0.361;
p
= 0.014) in the PCOS group.
Conclusion
Hp1-Hp2 polymorphism is not associated with PCOS but plasma Hp could be a potential biomarker for PCOS and its complications.</description><subject>Antioxidants</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>C-reactive protein</subject><subject>Complications</subject><subject>Gene polymorphism</subject><subject>Genotypes</subject><subject>Glucose</subject><subject>Gynecology</subject><subject>Haptoglobin</subject><subject>Hemoglobin</subject><subject>Heredity</subject><subject>Human Genetics</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic disorders</subject><subject>Oxidative stress</subject><subject>Polycystic ovary syndrome</subject><subject>Reproductive Medicine</subject><subject>Reproductive Physiology and Disease</subject><subject>Salts</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUtLxDAUhYMovn-AGwm4NXrzatKNIIM6guBG1yHtpDOVtqlJZmT-vdFR0YWrBO53zj3cg9AJhQsKoC4jBU0lAaoIBQ6Eb6F9KhUninPYzn-QmoAo9B46iPEFAErN-C7aY7rM-lLuIzO1Y_LzzlftgDu3cl08x9Uy4cEnPB0pmY4Mj75b9z6Mizb259gGh22Mvm5tcjP81qbFJ1GvY2pr7Fc2rHFcD7Pge3eEdhrbRXf89R6i59ubp8mUPDze3U-uH0gtFCTCC2lL0YhCNrQRTFS85tJK1VgnykYXDmbMFq5iBdBKa6oc6Ebxqqi4lY4rfoiuNr7jsurdrHZDCrYzY2j7HMd425q_k6FdmLlfGamo0Ixlg7Mvg-Bfly4m8-KXYciZDS0Vy2eVVGSKbqg6-BiDa342UDAfnZhNJyZ3Yj46MTxrTn9H-1F8l5ABtgFiHg1zF36t_tf1HRQ7mIY</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Carvalho, Laura M. L.</creator><creator>Ferreira, Cláudia N.</creator><creator>de Oliveira, Daisy K. D.</creator><creator>Rodrigues, Kathryna F.</creator><creator>Duarte, Rita C. F.</creator><creator>Teixeira, Márcia F. A.</creator><creator>Xavier, Luana B.</creator><creator>Candido, Ana Lúcia</creator><creator>Reis, Fernando M.</creator><creator>Silva, Ieda F. O.</creator><creator>Campos, Fernanda M. F.</creator><creator>Gomes, Karina B.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20171201</creationdate><title>Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome</title><author>Carvalho, Laura M. L. ; Ferreira, Cláudia N. ; de Oliveira, Daisy K. D. ; Rodrigues, Kathryna F. ; Duarte, Rita C. F. ; Teixeira, Márcia F. A. ; Xavier, Luana B. ; Candido, Ana Lúcia ; Reis, Fernando M. ; Silva, Ieda F. O. ; Campos, Fernanda M. F. ; Gomes, Karina B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-365a94f465f1f424b3c35a57fae49f86e0d2a6eb2601b8817e08f73b6b3a5e373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antioxidants</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>C-reactive protein</topic><topic>Complications</topic><topic>Gene polymorphism</topic><topic>Genotypes</topic><topic>Glucose</topic><topic>Gynecology</topic><topic>Haptoglobin</topic><topic>Hemoglobin</topic><topic>Heredity</topic><topic>Human Genetics</topic><topic>Inflammation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic disorders</topic><topic>Oxidative stress</topic><topic>Polycystic ovary syndrome</topic><topic>Reproductive Medicine</topic><topic>Reproductive Physiology and Disease</topic><topic>Salts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carvalho, Laura M. L.</creatorcontrib><creatorcontrib>Ferreira, Cláudia N.</creatorcontrib><creatorcontrib>de Oliveira, Daisy K. D.</creatorcontrib><creatorcontrib>Rodrigues, Kathryna F.</creatorcontrib><creatorcontrib>Duarte, Rita C. F.</creatorcontrib><creatorcontrib>Teixeira, Márcia F. A.</creatorcontrib><creatorcontrib>Xavier, Luana B.</creatorcontrib><creatorcontrib>Candido, Ana Lúcia</creatorcontrib><creatorcontrib>Reis, Fernando M.</creatorcontrib><creatorcontrib>Silva, Ieda F. O.</creatorcontrib><creatorcontrib>Campos, Fernanda M. F.</creatorcontrib><creatorcontrib>Gomes, Karina B.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carvalho, Laura M. L.</au><au>Ferreira, Cláudia N.</au><au>de Oliveira, Daisy K. D.</au><au>Rodrigues, Kathryna F.</au><au>Duarte, Rita C. F.</au><au>Teixeira, Márcia F. A.</au><au>Xavier, Luana B.</au><au>Candido, Ana Lúcia</au><au>Reis, Fernando M.</au><au>Silva, Ieda F. O.</au><au>Campos, Fernanda M. F.</au><au>Gomes, Karina B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>34</volume><issue>12</issue><spage>1691</spage><epage>1698</epage><pages>1691-1698</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
Proteomic studies suggest an association between haptoglobin (Hp) and polycystic ovary syndrome (PCOS). Hp is a classic inflammatory marker and binds to the intravascular hemoglobin, avoiding the oxidative damages that can be caused by free hemoglobin. Inflammation and oxidative stress are important in the pathogenesis of the PCOS, one of the most frequent metabolic diseases in women.
Methods
To validate these proteomic studies, we developed a controlled cross-sectional study that aimed to evaluate the Hp levels and allelic and genotypic frequencies of Hp1-Hp2 polymorphism in Brazilian women with PCOS. We also investigated the correlation between Hp levels and several important parameters in PCOS as follows: body mass index (BMI), waist circumference (WC), fasting glucose, post-prandial glucose, homeostatic model assessment (HOMA), lipid accumulation product (LAP), C-reactive protein (CRP), and metabolization test of tetrazolium salts (MTTs—serum antioxidant capacity).
Results
Plasma Hp levels were higher in the PCOS group than in controls [8.20 (4.04) g/L; 7.98 (3.31) g/L;
p
= 0.018]. No significant difference was observed in the frequency of Hp1-Hp2 genotypes under additive, recessive, or dominant model of inheritance between the PCOS and the control groups. Plasma Hp levels did not differ according to the genotype. However, plasma Hp showed a negative correlation with MTT (
r
= − 0.383;
p
= 0.028), as well as a positive correlation with CRP (
r
= 0.361;
p
= 0.014) in the PCOS group.
Conclusion
Hp1-Hp2 polymorphism is not associated with PCOS but plasma Hp could be a potential biomarker for PCOS and its complications.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28900795</pmid><doi>10.1007/s10815-017-1030-3</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1058-0468 |
| ispartof | Journal of assisted reproduction and genetics, 2017-12, Vol.34 (12), p.1691-1698 |
| issn | 1058-0468 1573-7330 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antioxidants Body mass Body mass index C-reactive protein Complications Gene polymorphism Genotypes Glucose Gynecology Haptoglobin Hemoglobin Heredity Human Genetics Inflammation Medicine Medicine & Public Health Metabolic disorders Oxidative stress Polycystic ovary syndrome Reproductive Medicine Reproductive Physiology and Disease Salts |
| title | Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome |
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