High-Confidence Qualitative Identification of Organophosphorus Nerve Agent Adducts to Human Butyrylcholinesterase

In this study, a data-dependent, high-resolution tandem mass spectrometry (ddHRMS/MS) method capable of detecting all organophosphorus nerve agent (OPNA) adducts to human butyrylcholinesterase (BChE) was developed. After an exposure event, immunoprecipitation from blood with a BChE-specific antibody...

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Veröffentlicht in:	Analytical chemistry (Washington) 2017-02, Vol.89 (3), p.1955-1964
Hauptverfasser:	Mathews, Thomas P, Carter, Melissa D, Johnson, Darryl, Isenberg, Samantha L, Graham, Leigh Ann, Thomas, Jerry D, Johnson, Rudolph C
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Adducts amino acids Analytical chemistry antibodies Biomarkers Biomarkers - blood blood serum Butyrylcholinesterase - blood Butyrylcholinesterase - chemistry Butyrylcholinesterase - drug effects cholinesterase Chromatography, High Pressure Liquid - methods Chromatography, High Pressure Liquid - standards Exposure False Negative Reactions False Positive Reactions Humans Immunoprecipitation Ions Mass spectrometry nerve agents Nerve Agents - standards Nerve Agents - toxicity Oligopeptides - blood Oligopeptides - chemistry Organophosphorus Compounds - standards Organophosphorus Compounds - toxicity pepsin Peptides precipitin tests Precursors Quality Control Reference Standards Signatures tandem mass spectrometry Tandem Mass Spectrometry - methods Tandem Mass Spectrometry - standards
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