Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents
Numerous studies have supported a role for oxidative stress in the development of ischemic damage and endothelial dysfunction. ( ) and ( ) extracts are polyphenolic-rich compounds that have proven to be efficient in the treatment of cardiovascular diseases. We studied the effect of extracts from and...
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| Veröffentlicht in: | International journal of molecular sciences 2017-11, Vol.18 (11), p.2412 |
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| creator | Cuevas-Durán, Raúl Enrique Medrano-Rodríguez, Juan Carlos Sánchez-Aguilar, María Soria-Castro, Elizabeth Rubio-Ruíz, María Esther Del Valle-Mondragón, Leonardo Sánchez-Mendoza, Alicia Torres-Narvaéz, Juan Carlos Pastelín-Hernández, Gustavo Ibarra-Lara, Luz |
| description | Numerous studies have supported a role for oxidative stress in the development of ischemic damage and endothelial dysfunction.
(
) and
(
) extracts are polyphenolic-rich compounds that have proven to be efficient in the treatment of cardiovascular diseases. We studied the effect of extracts from
and
on the myocardial damage associated with the oxidative status and to the production of different vasoactive agents. Rats were assigned to the following groups: (a) sham; (b) vehicle-treated myocardial infarction (MI) (MI-V); (c)
extract-treated myocardial infarction (MI-
); (d)
extract-treated myocardial infarction (MI-
); or (e)
-treated myocardial infarction (MI-
).
and
treatments increased total antioxidant capacity, the expression of superoxide dismutase (SOD)-Cu
/Zn
, SOD-Mn
, and catalase, with the subsequent decline of malondialdehyde and 8-hydroxy-2'-deoxyguanosine levels. The extracts diminished vasoconstrictor peptide levels (angiotensin II and endothelin-1), increased vasodilators agents (angiotensin 1-7 and bradikinin) and improved nitric oxide metabolism. Polyphenol treatment restored the left intraventricular pressure and cardiac mechanical work. We conclude that
and
treatment attenuate morphological and functional ischemic-related changes by both an oxidant load reduction and improvement of the balance between vasoconstrictors and vasodilators. |
| doi_str_mv | 10.3390/ijms18112412 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5713380</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1977975772</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-71278c5c8936e3fc7fec9988fa580e47be15e76ab54025cd648b7df1a7c97a7a3</originalsourceid><addsrcrecordid>eNpdkktv1DAUhSMEoqWwY40ssWHBgB9JHG-QRtOn1KqI1za6cW4yHiV2azvVzF_j19XTaauBlR_n87nHVzfL3jP6RQhFv5rVGFjFGM8Zf5EdspzzGaWlfLm3P8jehLCilAteqNfZAVdMFErww-zvyTp60DEQ15GFhwjYT-mw3oAGG5dAwLbkhwsjeGO3StcZbSwMJpB5jGgniEgugl7iaDS52jgNvjUwkGMYoUfSbMgxao8QjO3J9dq0EM0dkp_RYwg7-1RzSLdJj0sk371rJx2Nsw-hHuw0-QPBpaDbp_MebQxvs1cdDAHfPa5H2e_Tk1-L89nl9dnFYn450yLncSYZl5UudKVEiaLTskOtVFV1UFQUc9kgK1CW0BQ55YVuy7xqZNsxkFpJkCCOsm8735upGbHVqbaHob7xJvVkUzsw9b-KNcu6d3d1IZkQFU0Gnx4NvLudMMR6NEHjMIBFN4WaqTKXVFChEvrxP3TlJp-6vaWkVLKQkifq847S3oXgsXsOw2i9HYp6fygS_mH_A8_w0xSIe4YSuBo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1977975772</pqid></control><display><type>article</type><title>Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Cuevas-Durán, Raúl Enrique ; Medrano-Rodríguez, Juan Carlos ; Sánchez-Aguilar, María ; Soria-Castro, Elizabeth ; Rubio-Ruíz, María Esther ; Del Valle-Mondragón, Leonardo ; Sánchez-Mendoza, Alicia ; Torres-Narvaéz, Juan Carlos ; Pastelín-Hernández, Gustavo ; Ibarra-Lara, Luz</creator><creatorcontrib>Cuevas-Durán, Raúl Enrique ; Medrano-Rodríguez, Juan Carlos ; Sánchez-Aguilar, María ; Soria-Castro, Elizabeth ; Rubio-Ruíz, María Esther ; Del Valle-Mondragón, Leonardo ; Sánchez-Mendoza, Alicia ; Torres-Narvaéz, Juan Carlos ; Pastelín-Hernández, Gustavo ; Ibarra-Lara, Luz</creatorcontrib><description>Numerous studies have supported a role for oxidative stress in the development of ischemic damage and endothelial dysfunction.
(
) and
(
) extracts are polyphenolic-rich compounds that have proven to be efficient in the treatment of cardiovascular diseases. We studied the effect of extracts from
and
on the myocardial damage associated with the oxidative status and to the production of different vasoactive agents. Rats were assigned to the following groups: (a) sham; (b) vehicle-treated myocardial infarction (MI) (MI-V); (c)
extract-treated myocardial infarction (MI-
); (d)
extract-treated myocardial infarction (MI-
); or (e)
-treated myocardial infarction (MI-
).
and
treatments increased total antioxidant capacity, the expression of superoxide dismutase (SOD)-Cu
/Zn
, SOD-Mn
, and catalase, with the subsequent decline of malondialdehyde and 8-hydroxy-2'-deoxyguanosine levels. The extracts diminished vasoconstrictor peptide levels (angiotensin II and endothelin-1), increased vasodilators agents (angiotensin 1-7 and bradikinin) and improved nitric oxide metabolism. Polyphenol treatment restored the left intraventricular pressure and cardiac mechanical work. We conclude that
and
treatment attenuate morphological and functional ischemic-related changes by both an oxidant load reduction and improvement of the balance between vasoconstrictors and vasodilators.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms18112412</identifier><identifier>PMID: 29135932</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Angiotensin ; Angiotensin II ; Angiotensins - pharmacology ; Animals ; Antioxidants ; Biomarkers - metabolism ; Bradykinin - pharmacology ; Cardiovascular Agents - pharmacology ; Cardiovascular Agents - therapeutic use ; Cardiovascular diseases ; Catalase ; Chromatography, High Pressure Liquid ; Crataegus - chemistry ; Deoxyguanosine ; Endothelin 1 ; Endothelins ; Heart ; Heart attacks ; Heart diseases ; Heart Function Tests ; Hemodynamics - drug effects ; Ischemia ; Male ; Malondialdehyde ; Metabolism ; Myocardial infarction ; Myocardial Infarction - drug therapy ; Myocardial Infarction - pathology ; Myocardial Infarction - physiopathology ; Myocardium - pathology ; Myocardium - ultrastructure ; Nitric oxide ; Nitric Oxide Synthase Type III - metabolism ; Oxidative stress ; Oxidative Stress - drug effects ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Leaves - chemistry ; Rats ; Rats, Wistar ; Rodents ; Rosmarinus - chemistry ; Rosmarinus officinalis ; Superoxide dismutase ; Vasoactive agents ; Vasoconstriction - drug effects ; Vasoconstrictors ; Vasodilators</subject><ispartof>International journal of molecular sciences, 2017-11, Vol.18 (11), p.2412</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-71278c5c8936e3fc7fec9988fa580e47be15e76ab54025cd648b7df1a7c97a7a3</citedby><cites>FETCH-LOGICAL-c342t-71278c5c8936e3fc7fec9988fa580e47be15e76ab54025cd648b7df1a7c97a7a3</cites><orcidid>0000-0002-6697-0208 ; 0000-0002-8844-2078 ; 0000-0001-8659-6113</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713380/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713380/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29135932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cuevas-Durán, Raúl Enrique</creatorcontrib><creatorcontrib>Medrano-Rodríguez, Juan Carlos</creatorcontrib><creatorcontrib>Sánchez-Aguilar, María</creatorcontrib><creatorcontrib>Soria-Castro, Elizabeth</creatorcontrib><creatorcontrib>Rubio-Ruíz, María Esther</creatorcontrib><creatorcontrib>Del Valle-Mondragón, Leonardo</creatorcontrib><creatorcontrib>Sánchez-Mendoza, Alicia</creatorcontrib><creatorcontrib>Torres-Narvaéz, Juan Carlos</creatorcontrib><creatorcontrib>Pastelín-Hernández, Gustavo</creatorcontrib><creatorcontrib>Ibarra-Lara, Luz</creatorcontrib><title>Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Numerous studies have supported a role for oxidative stress in the development of ischemic damage and endothelial dysfunction.
(
) and
(
) extracts are polyphenolic-rich compounds that have proven to be efficient in the treatment of cardiovascular diseases. We studied the effect of extracts from
and
on the myocardial damage associated with the oxidative status and to the production of different vasoactive agents. Rats were assigned to the following groups: (a) sham; (b) vehicle-treated myocardial infarction (MI) (MI-V); (c)
extract-treated myocardial infarction (MI-
); (d)
extract-treated myocardial infarction (MI-
); or (e)
-treated myocardial infarction (MI-
).
and
treatments increased total antioxidant capacity, the expression of superoxide dismutase (SOD)-Cu
/Zn
, SOD-Mn
, and catalase, with the subsequent decline of malondialdehyde and 8-hydroxy-2'-deoxyguanosine levels. The extracts diminished vasoconstrictor peptide levels (angiotensin II and endothelin-1), increased vasodilators agents (angiotensin 1-7 and bradikinin) and improved nitric oxide metabolism. Polyphenol treatment restored the left intraventricular pressure and cardiac mechanical work. We conclude that
and
treatment attenuate morphological and functional ischemic-related changes by both an oxidant load reduction and improvement of the balance between vasoconstrictors and vasodilators.</description><subject>Angiotensin</subject><subject>Angiotensin II</subject><subject>Angiotensins - pharmacology</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Biomarkers - metabolism</subject><subject>Bradykinin - pharmacology</subject><subject>Cardiovascular Agents - pharmacology</subject><subject>Cardiovascular Agents - therapeutic use</subject><subject>Cardiovascular diseases</subject><subject>Catalase</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Crataegus - chemistry</subject><subject>Deoxyguanosine</subject><subject>Endothelin 1</subject><subject>Endothelins</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Heart Function Tests</subject><subject>Hemodynamics - drug effects</subject><subject>Ischemia</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Metabolism</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardium - pathology</subject><subject>Myocardium - ultrastructure</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase Type III - metabolism</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Rosmarinus - chemistry</subject><subject>Rosmarinus officinalis</subject><subject>Superoxide dismutase</subject><subject>Vasoactive agents</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstrictors</subject><subject>Vasodilators</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkktv1DAUhSMEoqWwY40ssWHBgB9JHG-QRtOn1KqI1za6cW4yHiV2azvVzF_j19XTaauBlR_n87nHVzfL3jP6RQhFv5rVGFjFGM8Zf5EdspzzGaWlfLm3P8jehLCilAteqNfZAVdMFErww-zvyTp60DEQ15GFhwjYT-mw3oAGG5dAwLbkhwsjeGO3StcZbSwMJpB5jGgniEgugl7iaDS52jgNvjUwkGMYoUfSbMgxao8QjO3J9dq0EM0dkp_RYwg7-1RzSLdJj0sk371rJx2Nsw-hHuw0-QPBpaDbp_MebQxvs1cdDAHfPa5H2e_Tk1-L89nl9dnFYn450yLncSYZl5UudKVEiaLTskOtVFV1UFQUc9kgK1CW0BQ55YVuy7xqZNsxkFpJkCCOsm8735upGbHVqbaHob7xJvVkUzsw9b-KNcu6d3d1IZkQFU0Gnx4NvLudMMR6NEHjMIBFN4WaqTKXVFChEvrxP3TlJp-6vaWkVLKQkifq847S3oXgsXsOw2i9HYp6fygS_mH_A8_w0xSIe4YSuBo</recordid><startdate>20171114</startdate><enddate>20171114</enddate><creator>Cuevas-Durán, Raúl Enrique</creator><creator>Medrano-Rodríguez, Juan Carlos</creator><creator>Sánchez-Aguilar, María</creator><creator>Soria-Castro, Elizabeth</creator><creator>Rubio-Ruíz, María Esther</creator><creator>Del Valle-Mondragón, Leonardo</creator><creator>Sánchez-Mendoza, Alicia</creator><creator>Torres-Narvaéz, Juan Carlos</creator><creator>Pastelín-Hernández, Gustavo</creator><creator>Ibarra-Lara, Luz</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6697-0208</orcidid><orcidid>https://orcid.org/0000-0002-8844-2078</orcidid><orcidid>https://orcid.org/0000-0001-8659-6113</orcidid></search><sort><creationdate>20171114</creationdate><title>Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents</title><author>Cuevas-Durán, Raúl Enrique ; Medrano-Rodríguez, Juan Carlos ; Sánchez-Aguilar, María ; Soria-Castro, Elizabeth ; Rubio-Ruíz, María Esther ; Del Valle-Mondragón, Leonardo ; Sánchez-Mendoza, Alicia ; Torres-Narvaéz, Juan Carlos ; Pastelín-Hernández, Gustavo ; Ibarra-Lara, Luz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-71278c5c8936e3fc7fec9988fa580e47be15e76ab54025cd648b7df1a7c97a7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Angiotensin</topic><topic>Angiotensin II</topic><topic>Angiotensins - pharmacology</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Biomarkers - metabolism</topic><topic>Bradykinin - pharmacology</topic><topic>Cardiovascular Agents - pharmacology</topic><topic>Cardiovascular Agents - therapeutic use</topic><topic>Cardiovascular diseases</topic><topic>Catalase</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Crataegus - chemistry</topic><topic>Deoxyguanosine</topic><topic>Endothelin 1</topic><topic>Endothelins</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart diseases</topic><topic>Heart Function Tests</topic><topic>Hemodynamics - drug effects</topic><topic>Ischemia</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Metabolism</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardium - pathology</topic><topic>Myocardium - ultrastructure</topic><topic>Nitric oxide</topic><topic>Nitric Oxide Synthase Type III - metabolism</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Rosmarinus - chemistry</topic><topic>Rosmarinus officinalis</topic><topic>Superoxide dismutase</topic><topic>Vasoactive agents</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstrictors</topic><topic>Vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cuevas-Durán, Raúl Enrique</creatorcontrib><creatorcontrib>Medrano-Rodríguez, Juan Carlos</creatorcontrib><creatorcontrib>Sánchez-Aguilar, María</creatorcontrib><creatorcontrib>Soria-Castro, Elizabeth</creatorcontrib><creatorcontrib>Rubio-Ruíz, María Esther</creatorcontrib><creatorcontrib>Del Valle-Mondragón, Leonardo</creatorcontrib><creatorcontrib>Sánchez-Mendoza, Alicia</creatorcontrib><creatorcontrib>Torres-Narvaéz, Juan Carlos</creatorcontrib><creatorcontrib>Pastelín-Hernández, Gustavo</creatorcontrib><creatorcontrib>Ibarra-Lara, Luz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cuevas-Durán, Raúl Enrique</au><au>Medrano-Rodríguez, Juan Carlos</au><au>Sánchez-Aguilar, María</au><au>Soria-Castro, Elizabeth</au><au>Rubio-Ruíz, María Esther</au><au>Del Valle-Mondragón, Leonardo</au><au>Sánchez-Mendoza, Alicia</au><au>Torres-Narvaéz, Juan Carlos</au><au>Pastelín-Hernández, Gustavo</au><au>Ibarra-Lara, Luz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2017-11-14</date><risdate>2017</risdate><volume>18</volume><issue>11</issue><spage>2412</spage><pages>2412-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Numerous studies have supported a role for oxidative stress in the development of ischemic damage and endothelial dysfunction.
(
) and
(
) extracts are polyphenolic-rich compounds that have proven to be efficient in the treatment of cardiovascular diseases. We studied the effect of extracts from
and
on the myocardial damage associated with the oxidative status and to the production of different vasoactive agents. Rats were assigned to the following groups: (a) sham; (b) vehicle-treated myocardial infarction (MI) (MI-V); (c)
extract-treated myocardial infarction (MI-
); (d)
extract-treated myocardial infarction (MI-
); or (e)
-treated myocardial infarction (MI-
).
and
treatments increased total antioxidant capacity, the expression of superoxide dismutase (SOD)-Cu
/Zn
, SOD-Mn
, and catalase, with the subsequent decline of malondialdehyde and 8-hydroxy-2'-deoxyguanosine levels. The extracts diminished vasoconstrictor peptide levels (angiotensin II and endothelin-1), increased vasodilators agents (angiotensin 1-7 and bradikinin) and improved nitric oxide metabolism. Polyphenol treatment restored the left intraventricular pressure and cardiac mechanical work. We conclude that
and
treatment attenuate morphological and functional ischemic-related changes by both an oxidant load reduction and improvement of the balance between vasoconstrictors and vasodilators.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>29135932</pmid><doi>10.3390/ijms18112412</doi><orcidid>https://orcid.org/0000-0002-6697-0208</orcidid><orcidid>https://orcid.org/0000-0002-8844-2078</orcidid><orcidid>https://orcid.org/0000-0001-8659-6113</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2017-11, Vol.18 (11), p.2412 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5713380 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Angiotensin Angiotensin II Angiotensins - pharmacology Animals Antioxidants Biomarkers - metabolism Bradykinin - pharmacology Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Cardiovascular diseases Catalase Chromatography, High Pressure Liquid Crataegus - chemistry Deoxyguanosine Endothelin 1 Endothelins Heart Heart attacks Heart diseases Heart Function Tests Hemodynamics - drug effects Ischemia Male Malondialdehyde Metabolism Myocardial infarction Myocardial Infarction - drug therapy Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardium - pathology Myocardium - ultrastructure Nitric oxide Nitric Oxide Synthase Type III - metabolism Oxidative stress Oxidative Stress - drug effects Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves - chemistry Rats Rats, Wistar Rodents Rosmarinus - chemistry Rosmarinus officinalis Superoxide dismutase Vasoactive agents Vasoconstriction - drug effects Vasoconstrictors Vasodilators |
| title | Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T13%3A22%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Extracts%20of%20Crataegus%20oxyacantha%20and%20Rosmarinus%20officinalis%20Attenuate%20Ischemic%20Myocardial%20Damage%20by%20Decreasing%20Oxidative%20Stress%20and%20Regulating%20the%20Production%20of%20Cardiac%20Vasoactive%20Agents&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Cuevas-Dur%C3%A1n,%20Ra%C3%BAl%20Enrique&rft.date=2017-11-14&rft.volume=18&rft.issue=11&rft.spage=2412&rft.pages=2412-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms18112412&rft_dat=%3Cproquest_pubme%3E1977975772%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1977975772&rft_id=info:pmid/29135932&rfr_iscdi=true |