Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation

Heparan sulfate (HS) is an important component of the extracellular matrix and cell surface, which plays a key role in cell-cell and cell-matrix interactions. Functional activity of HS directly depends on its structure, which determined by a complex system of HS biosynthetic enzymes. During malignan...

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Veröffentlicht in:	International journal of molecular sciences 2017-11, Vol.18 (11), p.2301
Hauptverfasser:	Ushakov, Victor S, Tsidulko, Alexandra Y, de La Bourdonnaye, Gabin, Kazanskaya, Galina M, Volkov, Alexander M, Kiselev, Roman S, Kobozev, Vyacheslav V, Kostromskaya, Diana V, Gaytan, Alexey S, Krivoshapkin, Alexei L, Aidagulova, Svetlana V, Grigorieva, Elvira V
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthesis Brain cancer Brain tumors Cell surface Comparative analysis Elongation Extracellular matrix Glioblastoma Glioma Glioma cells Heparan sulfate Microenvironments Polymerase chain reaction Sulfates Sulfation Transcription Tumor microenvironment
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