Respiratory distress in the neonate: Case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data

According to the American Academy of Pediatrics, approximately 10% of neonates need some assistance to begin breathing at birth, with up to 1% requiring extensive resuscitation [4]. [...]cyanosis is assessed by examining the oral mucosa for blue or gray discoloration and suggests inadequate gas exchange, while hypoxemia is signified by an oxygen saturation of less than 90% after 15min of life [8]. [...]to avoid selection bias, a restrictive time interval from maternal immunization to onset of Respiratory Distress in the Neonate should not be an integral part of such a definition. [...]we would like to acknowledge the Global Alignment of Immunization Safety Assessment in Pregnancy (GAIA) project, funded by the Bill and Melinda Gates Foundation - United States.