Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model

•Vaccination against maxadilan (MAX) protect mice from aggravated Leishmania infection.•Vaccination against MAX increases the number of IFN-γ-producing cells in draining lymph nodes.•The peptide MAX-CLDC vaccine improves host immunity against MAX-mediated immune modulation. Leishmaniasis is an arthr...

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Veröffentlicht in:	Vaccine 2017-12, Vol.35 (48), p.6611-6619
Hauptverfasser:	Wheat, William H., Arthun, Erik N., Spencer, John S., Regan, Daniel P., Titus, Richard G., Dow, Steven W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adjuvants, Immunologic - administration & dosage Alum Alum Compounds - administration & dosage Aluminum Aluminum sulfate amino acid sequences Animal models Animals Antigens Antisera antiserum arthropods Bone marrow Cancer Cationic Lipid DNA complexes, CLDC Cations CD4 antigen CD4-Positive T-Lymphocytes - immunology Dendritic cells Deoxyribonucleic acid Disease Models, Animal Disease transmission DNA DNA - chemistry Immune response Immune system Immunity Immunization Immunomodulation immunomodulators Infections inflammation injection site Insect Proteins - administration & dosage Insect Proteins - chemistry Insect Proteins - immunology Interleukin 4 Laboratory animals Leishmania Leishmania major Leishmania major - immunology Leishmaniasis Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - prevention & control Liposomes - administration & dosage Liposomes - chemistry Liposomes - immunology Lutzomyia longipalpis Lymph nodes Maxadilan Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Morbidity mortality Parasites Parasitic diseases Peptides Peptides - administration & dosage Peptides - immunology Phosphatase Proteins Psychodidae - chemistry Psychodidae - immunology Saliva Saliva - chemistry Sand Sand flies Vaccination Vaccine Vaccines Vector-borne diseases Vectors Vectors (Biology) γ-Interferon
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