Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma

IMPORTANCE: Retinoblastoma (Rb) is one of the first tumors to have a known genetic etiology. However, because biopsy of this tumor is contraindicated, it has not been possible to define the effects of secondary genetic changes on the disease course. OBJECTIVE: To investigate whether the aqueous humo...

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Veröffentlicht in:	JAMA ophthalmology 2017-11, Vol.135 (11), p.1221-1230
Hauptverfasser:	Berry, Jesse L, Xu, Liya, Murphree, A. Linn, Krishnan, Subramanian, Stachelek, Kevin, Zolfaghari, Emily, McGovern, Kathleen, Lee, Thomas C, Carlsson, Anders, Kuhn, Peter, Kim, Jonathan W, Cobrinik, David, Hicks, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous Humor - cytology Aqueous Humor - metabolism Biomarkers, Tumor - analysis Biopsy, Needle - methods Child, Preschool DNA, Neoplasm - analysis Eye Enucleation Genetic Markers Humans Infant Neoplasm Seeding Online First Original Investigation Retinal Neoplasms - diagnosis Retinal Neoplasms - surgery Retinoblastoma - diagnosis Retinoblastoma - surgery Retrospective Studies
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