The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

Ten-Eleven-Translocation-2 (Tet2) is a DNA methylcytosine dioxygenase that functions as a tumor suppressor in hematopoietic malignancies. We examined the role of Tet2 in tumor-tissue myeloid cells and found that Tet2 sustains the immunosuppressive function of these cells. We found that Tet2 expressi...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2017-08, Vol.47 (2), p.284-297.e5
Hauptverfasser:	Pan, Wen, Zhu, Shu, Qu, Kun, Meeth, Katrina, Cheng, Jijun, He, Kaixin, Ma, Hongdi, Liao, Yan, Wen, Xizhi, Roden, Christine, Tobiasova, Zuzana, Wei, Zheng, Zhao, Jun, Liu, Jun, Zheng, Ji, Guo, Bo, Khan, Sajid A., Bosenberg, Marcus, Flavell, Richard A., Lu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	5hmC 5mC Ablation Angiogenesis Animal models Animals Arg1 BMDM Cancer Carcinogenesis Clonal deletion Deoxyribonucleic acid Dioxygenase DNA DNA methylation DNA-Binding Proteins - metabolism Effector cells Female Gene expression HSC Humans Il1b Immunosuppression Immunosuppressive agents Inflammation Interleukin 1 receptors Kinases Lymphocytes Lymphocytes T Macrophages Male MDSC Melanoma Melanoma - immunology Melanoma, Experimental Mice Mice, Inbred C57BL Mice, Knockout Mutation MyD88 protein Myeloid cells Myeloid-Derived Suppressor Cells - immunology Proto-Oncogene Proteins - metabolism Rodents Skin Neoplasms - immunology Stem cells T-Lymphocytes - immunology TAM Tet3 Translocation Tumor Burden Tumor Escape Tumor suppressor genes Tumors YUMM1.7
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