Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1

Calcium phosphate-based mineralo-organic particles form spontaneously in the body and may represent precursors of ectopic calcification. We have shown earlier that these particles induce activation of caspase-1 and secretion of IL-1β by macrophages. However, whether the particles may produce other e...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.16628-16, Article 16628
Hauptverfasser:	Peng, Hsin-Hsin, Liu, Yu-Ju, Ojcius, David M., Lee, Chiou-Mei, Chen, Ren-Hao, Huang, Pei-Rong, Martel, Jan, Young, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 14/19 631/250 639/301 639/925 Animals Calcification (ectopic) Calcium (extracellular) Calcium phosphates Caspase Caspase-1 Cell activation Cell Line DNA-binding protein Extracellular Traps - immunology Female HMGB1 protein HMGB1 Protein - genetics HMGB1 Protein - metabolism Humanities and Social Sciences Humans IL-1β Immunity, Innate Immunomodulation Inflammation Innate immunity Leukocytes (neutrophilic) Macrophage Activation Macrophages Macrophages - immunology Macrophages - metabolism Male Mice Minerals - immunology Models, Molecular Monocytes multidisciplinary MyD88 protein Myeloid Differentiation Factor 88 - metabolism Neutrophils Neutrophils - immunology Neutrophils - metabolism Peritoneum Reactive Oxygen Species Rodents Science Science (multidisciplinary) Signal Transduction Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - metabolism Toll-like receptors Tumor Necrosis Factor-alpha - biosynthesis Tumor necrosis factor-α
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