Low-dose levels of bisphenol A inhibit telomerase via ER/GPR30-ERK signalling, impair DNA integrity and reduce cell proliferation in primary PBMC

Controversy exists about the human health risk of environmental exposure to bisphenol A (BPA). Telomerase activity is emerging both as biomarker and contributing factor for age-related diseases. The effects of BPA exposure at 1–1000 nM on telomerase, DNA integrity and cell proliferation were investi...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.16631-8, Article 16631
Hauptverfasser:	Herz, Corinna, Tran, Hoai Thi Thu, Schlotz, Nina, Michels, Karin, Lamy, Evelyn
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/95 38/77 692/699/67 692/700/2814 Age Antagonists Benzhydryl Compounds - administration & dosage Bioassays Bisphenol A Cell growth Cell proliferation Cell Proliferation - drug effects Cells, Cultured Comet assay Cytokines - metabolism Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects Environmental Exposure - adverse effects Environmental risk Enzyme-linked immunosorbent assay Exposure Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Flow cytometry Gene expression Health risks Humanities and Social Sciences Humans Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Metabolic pathways multidisciplinary Peripheral blood mononuclear cells Phenols - administration & dosage Receptors, Estrogen - metabolism Receptors, G-Protein-Coupled - metabolism Science Science (multidisciplinary) Signal transduction Signal Transduction - drug effects Telomerase Telomerase - antagonists & inhibitors Telomerase - genetics
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