Autonomous feedback loop of RUNX1-p53-CBFB in acute myeloid leukemia cells

Although runt-related transcription factor 1 (RUNX1) and its associating core binding factor-β (CBFB) play pivotal roles in leukemogenesis, and inhibition of RUNX1 has now been widely recognized as a novel strategy for anti-leukemic therapies, it has been elusive how leukemic cells could acquire the...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.16604-12, Article 16604
Hauptverfasser:	Morita, Ken, Noura, Mina, Tokushige, Chieko, Maeda, Shintaro, Kiyose, Hiroki, Kashiwazaki, Gengo, Taniguchi, Junichi, Bando, Toshikazu, Yoshida, Kenichi, Ozaki, Toshifumi, Matsuo, Hidemasa, Ogawa, Seishi, Liu, Pu Paul, Nakahata, Tatsutoshi, Sugiyama, Hiroshi, Adachi, Souichi, Kamikubo, Yasuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	38/15 38/70 38/89 631/67/1990/283/1897 692/699/67/395 96 96/95 Acute myeloid leukemia Chemotherapy Feedback Gene silencing Humanities and Social Sciences Leukemia Leukemogenesis multidisciplinary Myeloid leukemia p53 Protein Runx1 protein Science Science (multidisciplinary)
Online-Zugang:	Volltext
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