High-throughput annotation of full-length long noncoding RNAs with capture long-read sequencing

RNA Capture Long Seq (CLS) is a new method for transcript annotation that combines targeted RNA capture with long-read sequencing. CLS reannotates GENCODE lncRNAs and increases the number of validated splice junctions and transcript models for targeted loci. Accurate annotation of genes and their tr...

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Veröffentlicht in:	Nature genetics 2017-12, Vol.49 (12), p.1731-1740
Hauptverfasser:	Lagarde, Julien, Uszczynska-Ratajczak, Barbara, Carbonell, Silvia, Pérez-Lluch, Sílvia, Abad, Amaya, Davis, Carrie, Gingeras, Thomas R, Frankish, Adam, Harrow, Jennifer, Guigo, Roderic, Johnson, Rory
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/39 38/90 38/91 45 45/77 45/88 631/1647/1888/1891 631/1647/2017 631/1647/48 631/61/514/1949 631/61/514/2184 Agriculture Animal Genetics and Genomics Animal models Animals Annotations Automation Bioinformatics Biomedicine Cancer Cancer Research Computational Biology - methods Consortia DNA sequencing Gene expression Gene expression analysis Gene Expression Profiling - methods Gene Function Gene sequencing Genetic research Genomes Genomics Genomics - methods High-Throughput Nucleotide Sequencing - methods Human Genetics Humans Loci Methods Mice Molecular Sequence Annotation - methods Open Reading Frames - genetics Properties Protein structure Proteins Reproducibility of Results Ribonucleic acid RNA RNA probes RNA sequencing RNA, Long Noncoding - genetics Sequence annotation Software quality Studies Technology application Transcription
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