Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study
Arsenic, cadmium and lead are well-known environmental contaminants, and their toxicity at low concentration is the target of scientific concern. In this study, we aimed to identify the potential effects of prenatal heavy metal exposure on the birth outcomes among the Myanmar population. This study...
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| Veröffentlicht in: | International journal of environmental research and public health 2017-11, Vol.14 (11), p.1339 |
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| creator | Wai, Kyi Mar Mar, Ohn Kosaka, Satoko Umemura, Mitsutoshi Watanabe, Chiho |
| description | Arsenic, cadmium and lead are well-known environmental contaminants, and their toxicity at low concentration is the target of scientific concern. In this study, we aimed to identify the potential effects of prenatal heavy metal exposure on the birth outcomes among the Myanmar population. This study is part of a birth-cohort study conducted with 419 pregnant women in the Ayeyarwady Division, Myanmar. Face-to-face interviews were performed using a questionnaire, and maternal spot urine samples were collected at the third trimester. Birth outcomes were evaluated at delivery during the follow up. The median values of adjusted urinary arsenic, cadmium, selenium and lead concentration were 74.2, 0.9, 22.6 and 1.8 μg/g creatinine, respectively. Multivariable logistic regression revealed that prenatal cadmium exposure (adjusted odds ratio (OR) = 1.10; 95% confidence interval (CI): 1.01-1.21;
= 0.043), gestational age (adjusted OR = 0.83; 95% CI: 0.72-0.95;
= 0.009) and primigravida mothers (adjusted OR = 4.23; 95% CI: 1.31-13.65;
= 0.016) were the predictors of low birth weight. The present study identified that Myanmar mothers were highly exposed to cadmium. Prenatal maternal cadmium exposure was associated with an occurrence of low birth weight. |
| doi_str_mv | 10.3390/ijerph14111339 |
| format | Article |
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= 0.043), gestational age (adjusted OR = 0.83; 95% CI: 0.72-0.95;
= 0.009) and primigravida mothers (adjusted OR = 4.23; 95% CI: 1.31-13.65;
= 0.016) were the predictors of low birth weight. The present study identified that Myanmar mothers were highly exposed to cadmium. Prenatal maternal cadmium exposure was associated with an occurrence of low birth weight.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph14111339</identifier><identifier>PMID: 29099808</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Arsenic ; Birth weight ; Births ; Cadmium ; Childbirth & labor ; Cohort analysis ; Cohort Studies ; Confidence intervals ; Congenital Abnormalities - etiology ; Contaminants ; Creatinine ; Exposure ; Female ; Gestational Age ; Health risk assessment ; Heavy metals ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Lead ; Low birth weight ; Maternal Exposure - adverse effects ; Metals, Heavy - adverse effects ; Metals, Heavy - urine ; Myanmar ; Odds Ratio ; Population studies ; Pregnancy ; Pregnancy Complications - etiology ; Pregnancy Trimester, Third ; Premature Birth - chemically induced ; Prenatal experience ; Prenatal Exposure Delayed Effects ; Selenium ; Statistical analysis ; Toxicity ; Urine ; Womens health</subject><ispartof>International journal of environmental research and public health, 2017-11, Vol.14 (11), p.1339</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-a6bd068773e38b1267a3259440f49ddefac2874e8284d9198f879c541f45f413</citedby><cites>FETCH-LOGICAL-c484t-a6bd068773e38b1267a3259440f49ddefac2874e8284d9198f879c541f45f413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707978/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707978/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29099808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wai, Kyi Mar</creatorcontrib><creatorcontrib>Mar, Ohn</creatorcontrib><creatorcontrib>Kosaka, Satoko</creatorcontrib><creatorcontrib>Umemura, Mitsutoshi</creatorcontrib><creatorcontrib>Watanabe, Chiho</creatorcontrib><title>Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Arsenic, cadmium and lead are well-known environmental contaminants, and their toxicity at low concentration is the target of scientific concern. In this study, we aimed to identify the potential effects of prenatal heavy metal exposure on the birth outcomes among the Myanmar population. This study is part of a birth-cohort study conducted with 419 pregnant women in the Ayeyarwady Division, Myanmar. Face-to-face interviews were performed using a questionnaire, and maternal spot urine samples were collected at the third trimester. Birth outcomes were evaluated at delivery during the follow up. The median values of adjusted urinary arsenic, cadmium, selenium and lead concentration were 74.2, 0.9, 22.6 and 1.8 μg/g creatinine, respectively. Multivariable logistic regression revealed that prenatal cadmium exposure (adjusted odds ratio (OR) = 1.10; 95% confidence interval (CI): 1.01-1.21;
= 0.043), gestational age (adjusted OR = 0.83; 95% CI: 0.72-0.95;
= 0.009) and primigravida mothers (adjusted OR = 4.23; 95% CI: 1.31-13.65;
= 0.016) were the predictors of low birth weight. The present study identified that Myanmar mothers were highly exposed to cadmium. Prenatal maternal cadmium exposure was associated with an occurrence of low birth weight.</description><subject>Adult</subject><subject>Arsenic</subject><subject>Birth weight</subject><subject>Births</subject><subject>Cadmium</subject><subject>Childbirth & labor</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Congenital Abnormalities - etiology</subject><subject>Contaminants</subject><subject>Creatinine</subject><subject>Exposure</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Health risk assessment</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Lead</subject><subject>Low birth weight</subject><subject>Maternal Exposure - adverse effects</subject><subject>Metals, Heavy - adverse effects</subject><subject>Metals, Heavy - urine</subject><subject>Myanmar</subject><subject>Odds Ratio</subject><subject>Population studies</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - etiology</subject><subject>Pregnancy Trimester, Third</subject><subject>Premature Birth - chemically induced</subject><subject>Prenatal experience</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Selenium</subject><subject>Statistical analysis</subject><subject>Toxicity</subject><subject>Urine</subject><subject>Womens health</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVUU1PAjEQbYxGEL16NE08L7bb7rb1YIIEPxIIJnLx1JRt110CW2y7xP33LgEJnGYm782bl3kA3GLUJ0Sgh3Jh3LrAFGPczmegi9MURTRF-Pyo74Ar7xcIEU5TcQk6sUBCcMS74OvDmUoFtYRvRm0aODHbfvS7tr52BqpKw4HeGOcNfC5dKOC0DpldGQ_LCk4aVa2Ue4SDHRgNbWFdgJ-h1s01uMjV0pubfe2B2ctoNnyLxtPX9-FgHGWU0xCpdK5RyhkjhvA5jlOmSJwISlFOhdYmV1nMGTU85lQLLHjOmcgSinOa5BSTHnjaya7r-crozFTBqaVcu7J11kirSnmKVGUhv-1GJgwxwXgrcL8XcPanNj7Iha1d1VqWuMURYlRsz_R3rMxZ753JDxcwktsk5GkS7cLdsa8D_f_15A9_dIVC</recordid><startdate>20171103</startdate><enddate>20171103</enddate><creator>Wai, Kyi Mar</creator><creator>Mar, Ohn</creator><creator>Kosaka, Satoko</creator><creator>Umemura, Mitsutoshi</creator><creator>Watanabe, Chiho</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>20171103</creationdate><title>Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study</title><author>Wai, Kyi Mar ; Mar, Ohn ; Kosaka, Satoko ; Umemura, Mitsutoshi ; Watanabe, Chiho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-a6bd068773e38b1267a3259440f49ddefac2874e8284d9198f879c541f45f413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Arsenic</topic><topic>Birth weight</topic><topic>Births</topic><topic>Cadmium</topic><topic>Childbirth & labor</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Confidence intervals</topic><topic>Congenital Abnormalities - etiology</topic><topic>Contaminants</topic><topic>Creatinine</topic><topic>Exposure</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Health risk assessment</topic><topic>Heavy metals</topic><topic>Humans</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Lead</topic><topic>Low birth weight</topic><topic>Maternal Exposure - adverse effects</topic><topic>Metals, Heavy - adverse effects</topic><topic>Metals, Heavy - urine</topic><topic>Myanmar</topic><topic>Odds Ratio</topic><topic>Population studies</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - etiology</topic><topic>Pregnancy Trimester, Third</topic><topic>Premature Birth - chemically induced</topic><topic>Prenatal experience</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Selenium</topic><topic>Statistical analysis</topic><topic>Toxicity</topic><topic>Urine</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wai, Kyi Mar</creatorcontrib><creatorcontrib>Mar, Ohn</creatorcontrib><creatorcontrib>Kosaka, Satoko</creatorcontrib><creatorcontrib>Umemura, Mitsutoshi</creatorcontrib><creatorcontrib>Watanabe, Chiho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wai, Kyi Mar</au><au>Mar, Ohn</au><au>Kosaka, Satoko</au><au>Umemura, Mitsutoshi</au><au>Watanabe, Chiho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2017-11-03</date><risdate>2017</risdate><volume>14</volume><issue>11</issue><spage>1339</spage><pages>1339-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Arsenic, cadmium and lead are well-known environmental contaminants, and their toxicity at low concentration is the target of scientific concern. In this study, we aimed to identify the potential effects of prenatal heavy metal exposure on the birth outcomes among the Myanmar population. This study is part of a birth-cohort study conducted with 419 pregnant women in the Ayeyarwady Division, Myanmar. Face-to-face interviews were performed using a questionnaire, and maternal spot urine samples were collected at the third trimester. Birth outcomes were evaluated at delivery during the follow up. The median values of adjusted urinary arsenic, cadmium, selenium and lead concentration were 74.2, 0.9, 22.6 and 1.8 μg/g creatinine, respectively. Multivariable logistic regression revealed that prenatal cadmium exposure (adjusted odds ratio (OR) = 1.10; 95% confidence interval (CI): 1.01-1.21;
= 0.043), gestational age (adjusted OR = 0.83; 95% CI: 0.72-0.95;
= 0.009) and primigravida mothers (adjusted OR = 4.23; 95% CI: 1.31-13.65;
= 0.016) were the predictors of low birth weight. The present study identified that Myanmar mothers were highly exposed to cadmium. Prenatal maternal cadmium exposure was associated with an occurrence of low birth weight.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>29099808</pmid><doi>10.3390/ijerph14111339</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Arsenic Birth weight Births Cadmium Childbirth & labor Cohort analysis Cohort Studies Confidence intervals Congenital Abnormalities - etiology Contaminants Creatinine Exposure Female Gestational Age Health risk assessment Heavy metals Humans Infant, Low Birth Weight Infant, Newborn Lead Low birth weight Maternal Exposure - adverse effects Metals, Heavy - adverse effects Metals, Heavy - urine Myanmar Odds Ratio Population studies Pregnancy Pregnancy Complications - etiology Pregnancy Trimester, Third Premature Birth - chemically induced Prenatal experience Prenatal Exposure Delayed Effects Selenium Statistical analysis Toxicity Urine Womens health |
| title | Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study |
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