Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation

Membrane proteins, such as ion channels, interact dynamically with their lipid environment. Phosphoinositol-4,5-bisphosphate (PIP ) can directly or indirectly modify ion-channel properties. In auditory sensory hair cells of rats (Sprague Dawley) of either sex, PIP localizes within stereocilia, near...

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Veröffentlicht in:	The Journal of neuroscience 2017-11, Vol.37 (48), p.11632-11646
Hauptverfasser:	Effertz, Thomas, Becker, Lars, Peng, Anthony W, Ricci, Anthony J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adaptation, Physiological - physiology Animals Auditory perception Biological activity Bundling Calcium Calcium conductance Calcium ions Cochlea Conformation Data processing Female Hair Hair cells Hair Cells, Auditory - chemistry Hair Cells, Auditory - physiology Ion channels Lipids Male Mechanotransduction Mechanotransduction, Cellular - physiology Membrane proteins Myosin Penetration Phosphatidylinositol 4,5-diphosphate Phosphatidylinositol 4,5-Diphosphate - analysis Phosphatidylinositol 4,5-Diphosphate - physiology Properties (attributes) Proteins Rats Rats, Sprague-Dawley Reduction Resistance Signal transduction Tips
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