Nutrimiromics: Role of microRNAs and Nutrition in Modulating Inflammation and Chronic Diseases
Nutrimiromics studies the influence of the diet on the modification of gene expression due to epigenetic processes related to microRNAs (miRNAs), which may affect the risk for the development of chronic diseases. miRNAs are a class of non-coding endogenous RNA molecules that are usually involved in...
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| Veröffentlicht in: | Nutrients 2017-10, Vol.9 (11), p.1168 |
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| creator | Quintanilha, Bruna J Reis, Bruna Z Duarte, Graziela B Silva Cozzolino, Silvia M F Rogero, Marcelo M |
| description | Nutrimiromics studies the influence of the diet on the modification of gene expression due to epigenetic processes related to microRNAs (miRNAs), which may affect the risk for the development of chronic diseases. miRNAs are a class of non-coding endogenous RNA molecules that are usually involved in post-transcriptional gene silencing by inducing mRNA degradation or translational repression by binding to a target messenger RNA. They can be controlled by environmental and dietary factors, particularly by isolated nutrients or bioactive compounds, indicating that diet manipulation may hold promise as a therapeutic approach in modulating the risk of chronic diseases. This review summarizes the evidence regarding the influence of nutrients and bioactive compounds on the expression of miRNAs related to inflammation and chronic disease in several models (cell culture, animal models, and human trials). |
| doi_str_mv | 10.3390/nu9111168 |
| format | Article |
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They can be controlled by environmental and dietary factors, particularly by isolated nutrients or bioactive compounds, indicating that diet manipulation may hold promise as a therapeutic approach in modulating the risk of chronic diseases. 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They can be controlled by environmental and dietary factors, particularly by isolated nutrients or bioactive compounds, indicating that diet manipulation may hold promise as a therapeutic approach in modulating the risk of chronic diseases. This review summarizes the evidence regarding the influence of nutrients and bioactive compounds on the expression of miRNAs related to inflammation and chronic disease in several models (cell culture, animal models, and human trials).</description><subject>Animal models</subject><subject>Bioactive compounds</subject><subject>Biological activity</subject><subject>Cell culture</subject><subject>chronic diseases</subject><subject>Chronic illnesses</subject><subject>diet</subject><subject>Diseases</subject><subject>epigenetics</subject><subject>Gene expression</subject><subject>Gene silencing</subject><subject>Health risks</subject><subject>inflammation</subject><subject>messenger RNA</subject><subject>microRNA</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Non-coding RNA</subject><subject>Nutrients</subject><subject>Nutrition</subject><subject>Post-transcription</subject><subject>Review</subject><subject>RNA interference</subject><subject>therapeutics</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkU1LBSEUhiWKimrRHwihTS1uOero2CK43D6hD4jaJo6jZcxo6UzQv8_p41JtOhs9nIeXc94XgM0C7REi0L4fRJGLVQtgFSOOJ4xRsvjjvwI2UnpCY3HEGVkGK1ggzhFGq-D-auij61wMndPpAN6E1sBgYe5iuLmaJqh8Az-g3gUPnYeXoRla1Tv_AM-9bVXXqY_RCM4eY_BOwyOXjEomrYMlq9pkNr7eNXB3cnw7O5tcXJ-ez6YXE10i3E-soU1luCCoalhprChoUfOS6aJuMoEQUVbVHGNESGmxpjXhllOtNKsoY4isgcNP3eeh7kyjje-jauVzPk3FNxmUk78n3j3Kh_Aqy9ESOgrsfAnE8DKY1MvOJW3aVnkThiQxrpigCNPiX7QQJc9LcTKi23_QpzBEn53IFOdVRYQgmdr9pLLlKUVj53sXSI4Zy3nGmd36eeic_E6UvAPSo6ET</recordid><startdate>20171027</startdate><enddate>20171027</enddate><creator>Quintanilha, Bruna J</creator><creator>Reis, Bruna Z</creator><creator>Duarte, Graziela B Silva</creator><creator>Cozzolino, Silvia M F</creator><creator>Rogero, Marcelo M</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0517-1645</orcidid><orcidid>https://orcid.org/0000-0001-8726-8699</orcidid></search><sort><creationdate>20171027</creationdate><title>Nutrimiromics: Role of microRNAs and Nutrition in Modulating Inflammation and Chronic Diseases</title><author>Quintanilha, Bruna J ; 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| source | MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central(OpenAccess); EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Animal models Bioactive compounds Biological activity Cell culture chronic diseases Chronic illnesses diet Diseases epigenetics Gene expression Gene silencing Health risks inflammation messenger RNA microRNA MicroRNAs miRNA Non-coding RNA Nutrients Nutrition Post-transcription Review RNA interference therapeutics |
| title | Nutrimiromics: Role of microRNAs and Nutrition in Modulating Inflammation and Chronic Diseases |
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