JAK2-binding long noncoding RNA promotes breast cancer brain metastasis

Conventional therapies for breast cancer brain metastases (BCBMs) have been largely ineffective because of chemoresistance and impermeability of the blood-brain barrier. A comprehensive understanding of the underlying mechanism that allows breast cancer cells to infiltrate the brain is necessary to...

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Veröffentlicht in:	The Journal of clinical investigation 2017-12, Vol.127 (12), p.4498-4515
Hauptverfasser:	Wang, Shouyu, Liang, Ke, Hu, Qingsong, Li, Ping, Song, Jian, Yang, Yuedong, Yao, Jun, Mangala, Lingegowda Selanere, Li, Chunlai, Yang, Wenhao, Park, Peter K, Hawke, David H, Zhou, Jianwei, Zhou, Yan, Xia, Weiya, Hung, Mien-Chie, Marks, Jeffrey R, Gallick, Gary E, Lopez-Berestein, Gabriel, Flores, Elsa R, Sood, Anil K, Huang, Suyun, Yu, Dihua, Yang, Liuqing, Lin, Chunru
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Biomedical research Blood-brain barrier Brain Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain Neoplasms - secondary Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer metastasis Care and treatment Cell adhesion & migration Chemoresistance Development and progression Diagnosis Female Gene expression HEK293 Cells Human Umbilical Vein Endothelial Cells Humans Intercellular adhesion molecule 1 Interleukin 6 Janus kinase 2 Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Kinases Macrophages MCF-7 Cells Metastases Metastasis Mice Mice, Nude Monocyte chemoattractant protein 1 Nanoparticles Neoplasm Metastasis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism NIH 3T3 Cells Oncostatin M Phosphorylation Proteins Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Signal Transduction - genetics siRNA Stat3 protein Treatment resistance Tumor Microenvironment - genetics Tumors U937 Cells
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