MiR‐29b‐3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN

This study was aimed to explore the role of miR‐29b‐3p and PGRN in chondrocyte apoptosis and the initiation and progress of osteoarthritis (OA). Both miR‐29b‐3p and PGRN were up‐regulated in cartilage tissue from patients with OA. Transfection of miR‐29b‐3p mimic into rat primary chondrocytes and SW...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2017-12, Vol.21 (12), p.3347-3359
Hauptverfasser:	Chen, Lingqiang, Li, Qin, Wang, Jing, Jin, Song, Zheng, Hongmei, Lin, Jun, He, Fang, Zhang, Hong, Ma, Sha, Mei, Jian, Yu, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antagomirs - genetics Antagomirs - metabolism Apoptosis Apoptosis - genetics Arthritis Base Sequence Cartilage diseases Cartilage, Articular - metabolism Cartilage, Articular - pathology Cell Line, Tumor Cell proliferation Chondrocyte Chondrocytes Chondrocytes - metabolism Chondrocytes - pathology Chondrosarcoma Chromosome 3 Degeneration Female Gene Expression Regulation Genes, Reporter Humans Injection Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Knee Luciferases - genetics Luciferases - metabolism Male MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Middle Aged MiR‐29b‐3p mRNA Oligoribonucleotides - genetics Oligoribonucleotides - metabolism Original Osteoarthritis Osteoarthritis - genetics Osteoarthritis - metabolism Osteoarthritis - pathology Primary Cell Culture Progranulin Progranulins Rats Reporter gene RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Secretion Signal Transduction Transfection Wounds
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