The apolipoprotein A‐I mimetic peptide, D‐4F, restrains neointimal formation through heme oxygenase‐1 up‐regulation

D‐4F, an apolipoprotein A‐I (apoA‐I) mimetic peptide, possesses distinctly anti‐atherogenic effects. However, the biological functions and mechanisms of D‐4F on the hyperplasia of vascular smooth muscle cells (VSMCs) remain unclear. This study aimed to determine its roles in the proliferation and mi...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2017-12, Vol.21 (12), p.3810-3820
Hauptverfasser:	Liu, Donghui, Wu, Mengzhang, Du, Qian, Ding, Zhenzhen, Qian, Mingming, Tong, Zijia, Xu, Wenqi, Zhang, Le, Chang, He, Wang, Yan, Huang, Caihua, Lin, Donghai
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase ABCA1 protein AKT protein AMP AMP-activated protein kinase apoA‐I mimetic peptide Apolipoprotein A Apolipoprotein A-I Apolipoproteins ATP-binding protein Carotid artery Heme Heme oxygenase (decyclizing) HO‐1 Hyperplasia Inhibition Kinases Low density lipoprotein migration Muscles Original Oxidative stress Oxygenase proliferation Protoporphyrin Rats Reactive oxygen species Regulation D Restenosis Rodents siRNA Smooth muscle Up-regulation vascular smooth muscle cell Zinc
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