Mutational Landscape of cfDNA Identifies Distinct Molecular Features Associated With Therapeutic Response to First-Line Platinum-Based Doublet Chemotherapy in Patients with Advanced NSCLC

To investigate whether the mutational landscape of circulating cell-free DNA (cfDNA) could predict and dynamically monitor the response to first-line platinum-based chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC). Eligible patients were included and blood samples were colle...

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Veröffentlicht in:	Theranostics 2017-01, Vol.7 (19), p.4753-4762
Hauptverfasser:	Jiang, Tao, Li, Xuefei, Wang, Jianfei, Su, Chunxia, Han, Wenbo, Zhao, Chao, Wu, Fengying, Gao, Guanghui, Li, Wei, Chen, Xiaoxia, Li, Jiayu, Zhou, Fei, Zhao, Jing, Cai, Weijing, Zhang, Henghui, Du, Bo, Zhang, Jun, Ren, Shengxiang, Zhou, Caicun, Yu, Hui, Hirsch, Fred R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Carboplatin - administration & dosage Carboplatin - adverse effects Carboplatin - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Cell-Free Nucleic Acids - genetics Cisplatin - administration & dosage Cisplatin - adverse effects Cisplatin - therapeutic use Docetaxel Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Male Middle Aged Mutation Accumulation Research Paper Taxoids - administration & dosage Taxoids - adverse effects Taxoids - therapeutic use Tumor Suppressor Protein p53 - genetics
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