All-trans retinoic acid enhances cytotoxicity of CIK cells against human lung adenocarcinoma by upregulating MICA and IL-2 secretion

To determine the growth inhibition capability of all- trans retinoic acid (ATRA) with cytokine-induced killer cells (CIKs), we evaluated their effects, alone and in combination, on human lung carcinoma A549 cells. CIKs treated with ATRA significantly inhibited cell growth. Additionally, CIK with ATR...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.16481-12, Article 16481
Hauptverfasser:	Fan, Xiao-yan, Wang, Peng-yu, Zhang, Chao, Zhang, Yu-long, Fu, Yun, Zhang, Cong, Li, Qiao-xia, Zhou, Jie-na, Shan, Bao-en, He, Dong-wei
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/2 631/67/580 692/4028/67 Acids Adenocarcinoma Animals Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein Biomarkers Cancer therapies Caspase Caspase-3 Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Chemotherapy Cytokine-Induced Killer Cells - drug effects Cytokine-Induced Killer Cells - physiology Cytokines Cytotoxicity Cytotoxicity, Immunologic - drug effects Disease Models, Animal Flow cytometry Histocompatibility Antigens Class I - biosynthesis Humanities and Social Sciences Humans Immunomodulation - drug effects Immunotherapy Interleukin 2 Interleukin-2 - biosynthesis Invasiveness Killer cells Laboratory animals Lung cancer Lung carcinoma Major histocompatibility complex MICA protein Mice mRNA multidisciplinary Radiation therapy Retinoic acid Science Science (multidisciplinary) Survivin Tretinoin - pharmacology Tumors
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