Detectability of Breast Tumor by a Hand-held Impulse-Radar Detector: Performance Evaluation and Pilot Clinical Study
In this report, a hand-held impulse-radar breast cancer detector is presented and the detectability of malignant breast tumors is demonstrated in the clinical test at Hiroshima University Hospital, Hiroshima, Japan. The core functional parts of the detector consist of 65-nm technology complementary...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2017-11, Vol.7 (1), p.16353-11, Article 16353 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 11 |
|---|---|
| container_issue | 1 |
| container_start_page | 16353 |
| container_title | Scientific reports |
| container_volume | 7 |
| creator | Song, Hang Sasada, Shinsuke Kadoya, Takayuki Okada, Morihito Arihiro, Koji Xiao, Xia Kikkawa, Takamaro |
| description | In this report, a hand-held impulse-radar breast cancer detector is presented and the detectability of malignant breast tumors is demonstrated in the clinical test at Hiroshima University Hospital, Hiroshima, Japan. The core functional parts of the detector consist of 65-nm technology complementary metal-oxide-semiconductor (CMOS) integrated circuits covering the ultrawideband width from 3.1 to 10.6 GHz, which enable the generation and transmission of Gaussian monocycle pulse (GMP) with the pulse width of 160 ps and single port eight throw (SP8T) switching matrices for controlling the combination of 4 × 4 cross-shaped dome antenna array. The detector is designed to be placed on the breast with the patient in the supine position. The detectability of malignant tumors is confirmed in excised breast tissues after total mastectomy surgery. The three-dimensional positions of the tumors in the imaging results are consistent with the results of histopathology analysis. The clinical tests are conducted by a clinical doctor for five patients at the hospital. The malignant tumors include invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS). The final confocal imaging results are consistent with those of Magnetic Resonance Imaging (MRI), demonstrating the feasibility of the hand-held impulse-radar detector for malignant breast tumors. |
| doi_str_mv | 10.1038/s41598-017-16617-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5703952</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1968994531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-ae5c363d5d6077efb84319d546638093191bc0ac67fae87131af433c0069af263</originalsourceid><addsrcrecordid>eNp1kU9LHTEUxUNpqWL9Al2UQDfdTM2fSWbSRaG-WhWESmvX4U4mo5HM5DXJCO_bN89ReRbMIrlwf_fcHA5C7yn5TAlvj1JNhWorQpuKSllu-QrtM1KLinHGXu_Ue-gwpVtSjmCqpuot2mOKtqSRZB_l7zZbk6Fz3uUNDgM-jhZSxlfzGCLuNhjwGUx9dWN9j8_H9eyTrX5BDxEvoyF-wZc2DiGOMBmLT-7Az5BdmHCZw5fOh4xX3k3OgMe_89xv3qE3AxSdw4f3AP35cXK1Oqsufp6er75dVEbUJFdgheGS96KXpGns0LU1p6oXtZS8JarUtDMEjGwGsG1DOYWh5twQIhUMTPID9HXRXc_daHtjpxzB63V0I8SNDuD0887kbvR1uNOiIVwJVgQ-PQjE8He2KevRJWO9h8mGOWmqpFKMciEK-vE_9DbMcSr2tlSrVC04LRRbKBNDStEOT5-hRG9z1UuuuuSq73PVWxsfdm08jTymWAC-AKm0pmsbd3a_LPsP2BauJA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1968994531</pqid></control><display><type>article</type><title>Detectability of Breast Tumor by a Hand-held Impulse-Radar Detector: Performance Evaluation and Pilot Clinical Study</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Song, Hang ; Sasada, Shinsuke ; Kadoya, Takayuki ; Okada, Morihito ; Arihiro, Koji ; Xiao, Xia ; Kikkawa, Takamaro</creator><creatorcontrib>Song, Hang ; Sasada, Shinsuke ; Kadoya, Takayuki ; Okada, Morihito ; Arihiro, Koji ; Xiao, Xia ; Kikkawa, Takamaro</creatorcontrib><description>In this report, a hand-held impulse-radar breast cancer detector is presented and the detectability of malignant breast tumors is demonstrated in the clinical test at Hiroshima University Hospital, Hiroshima, Japan. The core functional parts of the detector consist of 65-nm technology complementary metal-oxide-semiconductor (CMOS) integrated circuits covering the ultrawideband width from 3.1 to 10.6 GHz, which enable the generation and transmission of Gaussian monocycle pulse (GMP) with the pulse width of 160 ps and single port eight throw (SP8T) switching matrices for controlling the combination of 4 × 4 cross-shaped dome antenna array. The detector is designed to be placed on the breast with the patient in the supine position. The detectability of malignant tumors is confirmed in excised breast tissues after total mastectomy surgery. The three-dimensional positions of the tumors in the imaging results are consistent with the results of histopathology analysis. The clinical tests are conducted by a clinical doctor for five patients at the hospital. The malignant tumors include invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS). The final confocal imaging results are consistent with those of Magnetic Resonance Imaging (MRI), demonstrating the feasibility of the hand-held impulse-radar detector for malignant breast tumors.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-16617-6</identifier><identifier>PMID: 29180760</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/1347 ; 631/67/2321 ; 639/166/987 ; Breast cancer ; Histopathology ; Humanities and Social Sciences ; Integrated circuits ; Invasiveness ; Magnetic resonance imaging ; Mammography ; multidisciplinary ; NMR ; Nuclear magnetic resonance ; Radar ; Science ; Science (multidisciplinary) ; Sensors ; Surgery ; Tumors</subject><ispartof>Scientific reports, 2017-11, Vol.7 (1), p.16353-11, Article 16353</ispartof><rights>The Author(s) 2017</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-ae5c363d5d6077efb84319d546638093191bc0ac67fae87131af433c0069af263</citedby><cites>FETCH-LOGICAL-c540t-ae5c363d5d6077efb84319d546638093191bc0ac67fae87131af433c0069af263</cites><orcidid>0000-0001-8957-602X ; 0000-0003-1623-869X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703952/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703952/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29180760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Hang</creatorcontrib><creatorcontrib>Sasada, Shinsuke</creatorcontrib><creatorcontrib>Kadoya, Takayuki</creatorcontrib><creatorcontrib>Okada, Morihito</creatorcontrib><creatorcontrib>Arihiro, Koji</creatorcontrib><creatorcontrib>Xiao, Xia</creatorcontrib><creatorcontrib>Kikkawa, Takamaro</creatorcontrib><title>Detectability of Breast Tumor by a Hand-held Impulse-Radar Detector: Performance Evaluation and Pilot Clinical Study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>In this report, a hand-held impulse-radar breast cancer detector is presented and the detectability of malignant breast tumors is demonstrated in the clinical test at Hiroshima University Hospital, Hiroshima, Japan. The core functional parts of the detector consist of 65-nm technology complementary metal-oxide-semiconductor (CMOS) integrated circuits covering the ultrawideband width from 3.1 to 10.6 GHz, which enable the generation and transmission of Gaussian monocycle pulse (GMP) with the pulse width of 160 ps and single port eight throw (SP8T) switching matrices for controlling the combination of 4 × 4 cross-shaped dome antenna array. The detector is designed to be placed on the breast with the patient in the supine position. The detectability of malignant tumors is confirmed in excised breast tissues after total mastectomy surgery. The three-dimensional positions of the tumors in the imaging results are consistent with the results of histopathology analysis. The clinical tests are conducted by a clinical doctor for five patients at the hospital. The malignant tumors include invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS). The final confocal imaging results are consistent with those of Magnetic Resonance Imaging (MRI), demonstrating the feasibility of the hand-held impulse-radar detector for malignant breast tumors.</description><subject>631/67/1347</subject><subject>631/67/2321</subject><subject>639/166/987</subject><subject>Breast cancer</subject><subject>Histopathology</subject><subject>Humanities and Social Sciences</subject><subject>Integrated circuits</subject><subject>Invasiveness</subject><subject>Magnetic resonance imaging</subject><subject>Mammography</subject><subject>multidisciplinary</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Radar</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sensors</subject><subject>Surgery</subject><subject>Tumors</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU9LHTEUxUNpqWL9Al2UQDfdTM2fSWbSRaG-WhWESmvX4U4mo5HM5DXJCO_bN89ReRbMIrlwf_fcHA5C7yn5TAlvj1JNhWorQpuKSllu-QrtM1KLinHGXu_Ue-gwpVtSjmCqpuot2mOKtqSRZB_l7zZbk6Fz3uUNDgM-jhZSxlfzGCLuNhjwGUx9dWN9j8_H9eyTrX5BDxEvoyF-wZc2DiGOMBmLT-7Az5BdmHCZw5fOh4xX3k3OgMe_89xv3qE3AxSdw4f3AP35cXK1Oqsufp6er75dVEbUJFdgheGS96KXpGns0LU1p6oXtZS8JarUtDMEjGwGsG1DOYWh5twQIhUMTPID9HXRXc_daHtjpxzB63V0I8SNDuD0887kbvR1uNOiIVwJVgQ-PQjE8He2KevRJWO9h8mGOWmqpFKMciEK-vE_9DbMcSr2tlSrVC04LRRbKBNDStEOT5-hRG9z1UuuuuSq73PVWxsfdm08jTymWAC-AKm0pmsbd3a_LPsP2BauJA</recordid><startdate>20171127</startdate><enddate>20171127</enddate><creator>Song, Hang</creator><creator>Sasada, Shinsuke</creator><creator>Kadoya, Takayuki</creator><creator>Okada, Morihito</creator><creator>Arihiro, Koji</creator><creator>Xiao, Xia</creator><creator>Kikkawa, Takamaro</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8957-602X</orcidid><orcidid>https://orcid.org/0000-0003-1623-869X</orcidid></search><sort><creationdate>20171127</creationdate><title>Detectability of Breast Tumor by a Hand-held Impulse-Radar Detector: Performance Evaluation and Pilot Clinical Study</title><author>Song, Hang ; Sasada, Shinsuke ; Kadoya, Takayuki ; Okada, Morihito ; Arihiro, Koji ; Xiao, Xia ; Kikkawa, Takamaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-ae5c363d5d6077efb84319d546638093191bc0ac67fae87131af433c0069af263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>631/67/1347</topic><topic>631/67/2321</topic><topic>639/166/987</topic><topic>Breast cancer</topic><topic>Histopathology</topic><topic>Humanities and Social Sciences</topic><topic>Integrated circuits</topic><topic>Invasiveness</topic><topic>Magnetic resonance imaging</topic><topic>Mammography</topic><topic>multidisciplinary</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Radar</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sensors</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Hang</creatorcontrib><creatorcontrib>Sasada, Shinsuke</creatorcontrib><creatorcontrib>Kadoya, Takayuki</creatorcontrib><creatorcontrib>Okada, Morihito</creatorcontrib><creatorcontrib>Arihiro, Koji</creatorcontrib><creatorcontrib>Xiao, Xia</creatorcontrib><creatorcontrib>Kikkawa, Takamaro</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Hang</au><au>Sasada, Shinsuke</au><au>Kadoya, Takayuki</au><au>Okada, Morihito</au><au>Arihiro, Koji</au><au>Xiao, Xia</au><au>Kikkawa, Takamaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detectability of Breast Tumor by a Hand-held Impulse-Radar Detector: Performance Evaluation and Pilot Clinical Study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-11-27</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>16353</spage><epage>11</epage><pages>16353-11</pages><artnum>16353</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>In this report, a hand-held impulse-radar breast cancer detector is presented and the detectability of malignant breast tumors is demonstrated in the clinical test at Hiroshima University Hospital, Hiroshima, Japan. The core functional parts of the detector consist of 65-nm technology complementary metal-oxide-semiconductor (CMOS) integrated circuits covering the ultrawideband width from 3.1 to 10.6 GHz, which enable the generation and transmission of Gaussian monocycle pulse (GMP) with the pulse width of 160 ps and single port eight throw (SP8T) switching matrices for controlling the combination of 4 × 4 cross-shaped dome antenna array. The detector is designed to be placed on the breast with the patient in the supine position. The detectability of malignant tumors is confirmed in excised breast tissues after total mastectomy surgery. The three-dimensional positions of the tumors in the imaging results are consistent with the results of histopathology analysis. The clinical tests are conducted by a clinical doctor for five patients at the hospital. The malignant tumors include invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS). The final confocal imaging results are consistent with those of Magnetic Resonance Imaging (MRI), demonstrating the feasibility of the hand-held impulse-radar detector for malignant breast tumors.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29180760</pmid><doi>10.1038/s41598-017-16617-6</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8957-602X</orcidid><orcidid>https://orcid.org/0000-0003-1623-869X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2017-11, Vol.7 (1), p.16353-11, Article 16353 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5703952 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; Nature Free; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 631/67/1347 631/67/2321 639/166/987 Breast cancer Histopathology Humanities and Social Sciences Integrated circuits Invasiveness Magnetic resonance imaging Mammography multidisciplinary NMR Nuclear magnetic resonance Radar Science Science (multidisciplinary) Sensors Surgery Tumors |
| title | Detectability of Breast Tumor by a Hand-held Impulse-Radar Detector: Performance Evaluation and Pilot Clinical Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T14%3A47%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Detectability%20of%20Breast%20Tumor%20by%20a%20Hand-held%20Impulse-Radar%20Detector:%20Performance%20Evaluation%20and%20Pilot%20Clinical%20Study&rft.jtitle=Scientific%20reports&rft.au=Song,%20Hang&rft.date=2017-11-27&rft.volume=7&rft.issue=1&rft.spage=16353&rft.epage=11&rft.pages=16353-11&rft.artnum=16353&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-017-16617-6&rft_dat=%3Cproquest_pubme%3E1968994531%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1968994531&rft_id=info:pmid/29180760&rfr_iscdi=true |