Exploring a causal role of DNA methylation in the relationship between maternal vitamin B12 during pregnancy and child's IQ at age 8, cognitive performance and educational attainment: a two-step Mendelian randomization study

An adequate intake of vitamin B12 during pregnancy plays an important role in offspring neurodevelopment, potentially via epigenetic processes. We used a two-step Mendelian randomization approach to assess whether DNA methylation plays a mediating and causal role in associations between maternal vit...

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Veröffentlicht in:	Human molecular genetics 2017-08, Vol.26 (15), p.3001-3013
Hauptverfasser:	Caramaschi, Doretta, Sharp, Gemma C, Nohr, Ellen A, Berryman, Katie, Lewis, Sarah J, Davey Smith, George, Relton, Caroline L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Association Studies Child Cognition - drug effects DNA Methylation - genetics DNA Methylation - physiology Epigenesis, Genetic - genetics Family Female Fetal Blood - metabolism Genotype Humans Intelligence - drug effects Intelligence Tests Longitudinal Studies Male Mendelian Randomization Analysis Pregnancy Prenatal Exposure Delayed Effects - genetics Prenatal Exposure Delayed Effects - metabolism Random Allocation Vitamin B 12 - metabolism
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