New free-exchange model of EmrE transport

EmrE is a small multidrug resistance transporter found in Escherichia coli that confers resistance to toxic polyaromatic cations due to its proton-coupled antiport of these substrates. Here we show that EmrE breaks the rules generally deemed essential for coupled antiport. NMR spectra reveal that Em...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-11, Vol.114 (47), p.E10083-E10091
Hauptverfasser:	Robinson, Anne E., Thomas, Nathan E., Morrison, Emma A., Balthazor, Bryan M., Henzler-Wildman, Katherine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiport Biological Sciences Cations Drug delivery systems E coli Efflux Exchanging Multidrug resistance Multidrug resistant organisms NMR Nuclear magnetic resonance PNAS Plus Protons Substrates
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