Expression and purification of functional insulin and insulin-like growth factor 1 holoreceptors from mammalian cells

The insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) are receptor tyrosine kinases (RTKs) involved in the regulation of many important cellular processes. The current proposed models of activation are derived from structural studies using soluble extracellular domains and cyto...

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Veröffentlicht in:	Analytical biochemistry 2017-11, Vol.536, p.69-77
Hauptverfasser:	Delle Bovi, Richard J., Miller, W. Todd
Format:	Artikel
Sprache:	eng
Schlagworte:	affinity chromatography Antigens, CD - genetics Antigens, CD - isolation & purification Antigens, CD - metabolism Chromatography, Affinity Detergents HEK293 Cells Humans insulin Insulin receptor insulin receptors Insulin-like growth factor 1 receptor insulin-like growth factor I insulin-like growth factor I receptor ligands mammals Membrane proteins protein phosphorylation Receptor tyrosine kinases Receptor, IGF Type 1 Receptor, Insulin - genetics Receptor, Insulin - isolation & purification Receptor, Insulin - metabolism Receptors, Somatomedin - genetics Receptors, Somatomedin - isolation & purification Receptors, Somatomedin - metabolism resins solubilization Streptavidin-binding peptide tyrosine
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