Endothelial cell-surface tissue transglutaminase inhibits neutrophil adhesion by binding and releasing nitric oxide

Nitric oxide (NO) produced by endothelial cells in response to cytokines displays anti-inflammatory activity by preventing the adherence, migration and activation of neutrophils. The molecular mechanism by which NO operates at the blood-endothelium interface to exert anti-inflammatory properties is...

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Veröffentlicht in:	Scientific reports 2017-11, Vol.7 (1), p.16163-9, Article 16163
Hauptverfasser:	Lai, Thung-S., Lindberg, Robert A., Zhou, Hua-Lin, Haroon, Zishan A., Dewhirst, Mark W., Hausladen, Alfred, Juang, Y.-L., Stamler, Jonathan S., Greenberg, Charles S.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 631/80/79/750 692/4019/592/75 Alkylation Antiinflammatory agents Cell activation Cell Adhesion - physiology Cell surface Endothelial cells Endothelium GTP-Binding Proteins - metabolism Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - metabolism Humanities and Social Sciences Humans Inflammation Leukocyte migration Leukocytes (neutrophilic) multidisciplinary Neutrophils Neutrophils - cytology Neutrophils - metabolism Nitric oxide Nitric Oxide - metabolism Science Science (multidisciplinary) Transglutaminase 2 Transglutaminases - metabolism Tumor necrosis factor-α
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