Pharmacokinetics and Tissue Penetration of Ceftolozane-Tazobactam in Diabetic Patients with Lower Limb Infections and Healthy Adult Volunteers

Ceftolozane-tazobactam displays potent activity against Gram-negative bacteria that can cause diabetic foot infections (DFI), making it an attractive treatment option when few alternatives exist. The pharmacokinetics and tissue penetration of ceftolozane-tazobactam at 1.5 g every 8 h (q8h) in patien...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2017-12, Vol.61 (12)
Hauptverfasser:	Monogue, Marguerite L, Stainton, Sean M, Baummer-Carr, Arlinda, Shepard, Ashley K, Nugent, James F, Kuti, Joseph L, Nicolau, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Cephalosporins Clinical Therapeutics Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetic Foot Gram-Negative Bacterial Infections Penicillanic Acid
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