The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs

The emergence and spread of drug-resistant strains possibly threaten our ability to treat this disease in the future. Even though two new antitubercular drugs have recently been introduced, there is still the need to design new molecules whose mechanisms of action could reduce the length of treatmen...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2017-12, Vol.61 (12)
Hauptverfasser:	Pisu, Davide, Provvedi, Roberta, Espinosa, Dulce Mata, Payan, Jorge Barrios, Boldrin, Francesca, Palù, Giorgio, Hernandez-Pando, Rogelio, Manganelli, Riccardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents Bacterial Proteins Drug Tolerance Ethambutol Gene Expression Regulation, Bacterial Mechanisms of Action: Physiological Effects Mycobacterium tuberculosis Sigma Factor
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